AKT1S1

Protein-coding gene in the species Homo sapiens

AKT1S1
Identifiers
AliasesAKT1S1, Lobe, PRAS40, AKT1 substrate 1
External IDsOMIM: 610221; MGI: 1914855; HomoloGene: 12162; GeneCards: AKT1S1; OMA:AKT1S1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for AKT1S1
Genomic location for AKT1S1
Band19q13.33Start49,869,033 bp[1]
End49,878,459 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for AKT1S1
Genomic location for AKT1S1
Band7|7 B3Start44,498,415 bp[2]
End44,504,845 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • muscle of thigh

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • mucosa of transverse colon

  • skin of leg

  • apex of heart

  • gastric mucosa
Top expressed in
  • muscle of thigh

  • yolk sac

  • extensor digitorum longus muscle

  • knee joint

  • molar

  • lip

  • vastus lateralis muscle

  • atrium

  • esophagus

  • plantaris muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • TORC1 complex
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
  • protein-containing complex
Biological process
  • regulation of cellular response to heat
  • negative regulation of TOR signaling
  • regulation of neuron apoptotic process
  • negative regulation of protein kinase activity
  • negative regulation of cell size
  • neurotrophin TRK receptor signaling pathway
  • TORC1 signaling
  • regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84335

67605

Ensembl

ENSG00000204673

ENSMUSG00000011096

UniProt

Q96B36

Q9D1F4

RefSeq (mRNA)

NM_032375
NM_001098632
NM_001098633
NM_001278159
NM_001278160

NM_001253920
NM_001290694
NM_001290695
NM_026270
NM_001382480

NM_001382481
NM_001382482
NM_001382483
NM_001382484

RefSeq (protein)

NP_001092102
NP_001092103
NP_001265088
NP_001265089
NP_115751

NP_001240849
NP_001277623
NP_001277624
NP_080546
NP_001369409

NP_001369410
NP_001369411
NP_001369412
NP_001369413

Location (UCSC)Chr 19: 49.87 – 49.88 MbChr 7: 44.5 – 44.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011096 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
  6. ^ "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience. 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMC 6730448. PMID 14973226.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica. 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771. S2CID 12827916.
  • Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.
  • Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry. 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.
  • Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry. 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.


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