ANKRD27

Protein-coding gene in the species Homo sapiens
ANKRD27
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4B93, 4CYM, 4CZ2

Identifiers
AliasesANKRD27, VARP, PP12899, ankyrin repeat domain 27
External IDsMGI: 2444103; HomoloGene: 12956; GeneCards: ANKRD27; OMA:ANKRD27 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ANKRD27
Genomic location for ANKRD27
Band19q13.11Start32,597,006 bp[1]
End32,676,597 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ANKRD27
Genomic location for ANKRD27
Band7|7 B2Start35,285,669 bp[2]
End35,338,651 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Epithelium of choroid plexus

  • amniotic fluid

  • skin of thigh

  • palpebral conjunctiva

  • Brodmann area 23

  • tail of epididymis

  • seminal vesicula

  • epithelium of nasopharynx

  • lower lobe of lung

  • testicle
Top expressed in
  • neural layer of retina

  • ascending aorta

  • lacrimal gland

  • zygote

  • aortic valve

  • tail of embryo

  • lumbar spinal ganglion

  • parotid gland

  • epiblast

  • oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • GTPase activator activity
  • guanyl-nucleotide exchange factor activity
  • protein binding
  • SNARE binding
Cellular component
  • endosome
  • late endosome
  • membrane
  • melanosome
  • plasma membrane
  • transport vesicle
  • tubular endosome
  • early endosome
  • lysosome
  • cytoplasmic vesicle membrane
  • cytoplasmic vesicle
  • cytosol
  • neuron projection
Biological process
  • negative regulation of SNARE complex assembly
  • early endosome to late endosome transport
  • positive regulation of dendrite morphogenesis
  • endosome to melanosome transport
  • protein transport
  • positive regulation of GTPase activity
  • neuron projection morphogenesis
  • transport
  • regulation of molecular function
  • positive regulation of neuron projection development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84079

245886

Ensembl

ENSG00000105186

ENSMUSG00000034867

UniProt

Q96NW4

Q3UMR0

RefSeq (mRNA)

NM_032139

NM_145633
NM_178263
NM_001358876

RefSeq (protein)

NP_115515

NP_663608
NP_839994
NP_001345805

Location (UCSC)Chr 19: 32.6 – 32.68 MbChr 7: 35.29 – 35.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105186 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034867 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci. 119 (Pt 6): 1053–62. doi:10.1242/jcs.02810. PMID 16525121.
  7. ^ "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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