ARHGAP44

Protein-coding gene in the species Homo sapiens

ARHGAP44
Identifiers
AliasesARHGAP44, NPC-A-10, RICH2, Rho GTPase activating protein 44
External IDsOMIM: 617716; MGI: 2144423; HomoloGene: 65284; GeneCards: ARHGAP44; OMA:ARHGAP44 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ARHGAP44
Genomic location for ARHGAP44
Band17p12Start12,789,498 bp[1]
End12,991,643 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ARHGAP44
Genomic location for ARHGAP44
Band11|11 B3Start64,892,865 bp[2]
End65,053,787 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • Brodmann area 23

  • middle temporal gyrus

  • buccal mucosa cell

  • germinal epithelium

  • primary visual cortex

  • cerebellar cortex

  • cerebellar hemisphere

  • prefrontal cortex

  • right hemisphere of cerebellum
Top expressed in
  • medial vestibular nucleus

  • pontine nuclei

  • deep cerebellar nuclei

  • substantia nigra

  • medial dorsal nucleus

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • dorsal tegmental nucleus

  • piriform cortex

  • primary motor cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • phospholipid binding
  • GTPase activator activity
Cellular component
  • cytoplasm
  • recycling endosome
  • cytosol
  • cell junction
  • endosome
  • dendritic spine
  • cell projection
  • synapse
  • leading edge membrane
  • glutamatergic synapse
  • intracellular anatomical structure
  • postsynaptic density
  • presynaptic active zone
Biological process
  • positive regulation of GTPase activity
  • regulation of small GTPase mediated signal transduction
  • signal transduction
  • exocytosis
  • regulation of actin cytoskeleton organization
  • regulation of GTPase activity
  • regulation of dendritic spine morphogenesis
  • modification of dendritic spine
  • neurotransmitter receptor transport, endosome to postsynaptic membrane
  • negative regulation of Rac protein signal transduction
  • modification of postsynaptic structure
  • regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9912

216831

Ensembl

ENSG00000006740

ENSMUSG00000033389

UniProt

Q17R89

Q5SSM3

RefSeq (mRNA)

NM_014859
NM_001321164
NM_001321166
NM_001321167
NM_001321168

NM_001099288
NM_175003

RefSeq (protein)

NP_001308093
NP_001308095
NP_001308096
NP_001308097
NP_055674

NP_001092758
NP_778168
NP_001395152
NP_001395153
NP_001395155

NP_001395157

Location (UCSC)Chr 17: 12.79 – 12.99 MbChr 11: 64.89 – 65.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase activating protein 44 is a protein in humans that is encoded by the ARHGAP44 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006740 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033389 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Rho GTPase activating protein 44". Retrieved 2013-05-13.

Further reading

  • Sarowar T, Grabrucker S, Föhr K, Mangus, Eckert M, Bockmann J, Boeckers TM, Grabrucker AM (2016). "Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2". Molecular Brain. 9 (28): 28. doi:10.1186/s13041-016-0206-6. PMC 4788860. PMID 26969129.