ARIH1

Protein-coding gene in humans

ARIH1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1WD2, 2M9Y, 4KBL, 4KC9

Identifiers

Aliases

ARIH1, ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1

External IDs

OMIM: 605624; MGI: 1344363; HomoloGene: 111871; GeneCards: ARIH1; OMA:ARIH1 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q24.1	Start	72,474,330 bp^[1]
Band	15q24.1	End	72,602,987 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 B	Start	59,295,541 bp^[2]
Band	9\|9 B	End	59,393,901 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

left testis

right testis

ventricular zone

sural nerve

ganglionic eminence

epithelium of colon

stromal cell of endometrium

muscle of thigh

Achilles tendon

Top expressed in

zygote

secondary oocyte

seminiferous tubule

extensor digitorum longus muscle

spermatid

plantaris muscle

neural layer of retina

triceps brachii muscle

tail of embryo

temporal muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ubiquitin-like protein transferase activity protein binding metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin-protein transferase activity transferase activity ubiquitin conjugating enzyme binding zinc ion binding
Cellular component	cytoplasm ubiquitin ligase complex cytosol nucleus Cajal body nuclear body SCF ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex Lewy body
Biological process	protein polyubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


25820


23806

Ensembl


ENSG00000166233


ENSMUSG00000025234

UniProt


Q9Y4X5


Q9Z1K5

RefSeq (mRNA)


NM_005744


NM_019927

RefSeq (protein)


NP_005735


NP_064311

Location (UCSC)

Chr 15: 72.47 – 72.6 Mb

Chr 9: 59.3 – 59.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.^[5]^[6]

Interactions

ARIH1 has been shown to interact with:

EIF4E2,^[7] and
UBE2L3.^[5]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025234 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
^ "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".
^ ^a ^b Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/s0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.
^ Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816.

External links

Human ARIH1 genome location and ARIH1 gene details page in the UCSC Genome Browser.

Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC 1461160. PMID 10880484.
Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.
Tan NG, Ardley HC, Rose SA, Leek JP, Markham AF, Robinson PA (2001). "Characterisation of the human and mouse orthologues of the Drosophila ariadne gene". Cytogenet. Cell Genet. 90 (3–4): 242–5. doi:10.1159/000056780. PMID 11124525. S2CID 12113119.
Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.
Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816.
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.
Capili AD, Edghill EL, Wu K, Borden KL (2004). "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING". J. Mol. Biol. 340 (5): 1117–29. doi:10.1016/j.jmb.2004.05.035. PMID 15236971.
Parelkar SS, Cadena JG, Kim C, Wang Z, Sugal R, Bentley B, Moral L, Ardley HC, Schwartz LM (2012). "The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies". J. Mol. Neurosci. 46 (1): 109–21. doi:10.1007/s12031-011-9535-1. PMID 21590270. S2CID 17276111.