ARPP-19

Protein-coding gene in the species Homo sapiens

ARPP19
Identifiers
AliasesARPP19, ARPP-16, ARPP-19, ARPP16, ENSAL, cAMP regulated phosphoprotein 19kDa, cAMP regulated phosphoprotein 19
External IDsOMIM: 605487; MGI: 1891691; HomoloGene: 21318; GeneCards: ARPP19; OMA:ARPP19 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ARPP19
Genomic location for ARPP19
Band15q21.2Start52,547,045 bp[1]
End52,569,883 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ARPP19
Genomic location for ARPP19
Band9|9 DStart75,037,614 bp[2]
End75,060,313 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • external globus pallidus

  • nucleus accumbens

  • putamen

  • caudate nucleus

  • optic nerve

  • middle frontal gyrus

  • Brodmann area 10

  • dorsolateral prefrontal cortex

  • Brodmann area 9
Top expressed in
  • superior frontal gyrus

  • olfactory tubercle

  • yolk sac

  • globus pallidus

  • primary motor cortex

  • nucleus accumbens

  • prefrontal cortex

  • primary visual cortex

  • right kidney

  • embryo
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein phosphatase 2A binding
  • potassium channel regulator activity
  • signaling receptor binding
  • phosphatase inhibitor activity
  • protein phosphatase inhibitor activity
  • protein phosphatase regulator activity
Cellular component
  • nucleoplasm
  • cytoplasm
Biological process
  • cell division
  • positive regulation of glucose import
  • cell cycle
  • positive regulation of gluconeogenesis
  • G2/M transition of mitotic cell cycle
  • negative regulation of catalytic activity
  • negative regulation of protein dephosphorylation
  • mitotic cell cycle
  • negative regulation of phosphoprotein phosphatase activity
  • regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10776

59046

Ensembl

ENSG00000128989

ENSMUSG00000007656

UniProt

P56211

P56212

RefSeq (mRNA)

NM_001306191
NM_001306195
NM_001306196
NM_006628
NM_001330309

NM_001142655
NM_021548

RefSeq (protein)

NP_001293120
NP_001293124
NP_001293125
NP_001317238
NP_006619

NP_001136127
NP_067523
NP_001344807
NP_001344808
NP_001344809

NP_001344810

Location (UCSC)Chr 15: 52.55 – 52.57 MbChr 9: 75.04 – 75.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cAMP-regulated phosphoprotein 19 is a protein that in humans is encoded by the ARPP19 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128989 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007656 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x. PMID 11279279.
  6. ^ Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. doi:10.1006/bbrc.1996.0938. PMID 8687439.
  7. ^ "Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".

Further reading

  • Kim SH, Nairn AC, Cairns N, Lubec G (2001). "Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease". Protein Expression in Down Syndrome Brain. pp. 263–72. doi:10.1007/978-3-7091-6262-0_21. ISBN 978-3-211-83704-7. PMID 11771749. {{cite book}}: |journal= ignored (help)
  • Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
  • Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (1998). "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
  • Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
  • Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P (1990). "Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19". J. Biol. Chem. 265 (16): 9476–84. doi:10.1016/S0021-9258(19)38874-X. PMID 2160982.


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