ASXL3

Protein-coding gene in the species Homo sapiens
ASXL3
Identifiers
AliasesASXL3, BRPS, KIAA1713, additional sex combs like 3, transcriptional regulator, ASXL transcriptional regulator 3
External IDsOMIM: 615115; MGI: 2685175; HomoloGene: 19371; GeneCards: ASXL3; OMA:ASXL3 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ASXL3
Genomic location for ASXL3
Band18q12.1Start33,578,219 bp[1]
End33,751,195 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for ASXL3
Genomic location for ASXL3
Band18|18 A2Start22,477,303 bp[2]
End22,663,284 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • secondary oocyte

  • sperm

  • testicle

  • ganglionic eminence

  • Brodmann area 23

  • middle temporal gyrus

  • sural nerve

  • endothelial cell

  • ventricular zone
Top expressed in
  • superior cervical ganglion

  • Rostral migratory stream

  • hand

  • trigeminal ganglion

  • genital tubercle

  • maxillary prominence

  • otolith organ

  • mandibular prominence

  • utricle

  • ganglionic eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • DNA binding
  • chromatin binding
  • peroxisome proliferator activated receptor binding
Cellular component
  • nucleus
  • PR-DUB complex
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • animal organ morphogenesis
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80816

211961

Ensembl

ENSG00000141431

ENSMUSG00000045215

UniProt

Q9C0F0

Q8C4A5

RefSeq (mRNA)

NM_030632

NM_001167777

RefSeq (protein)

NP_085135

NP_001161249

Location (UCSC)Chr 18: 33.58 – 33.75 MbChr 18: 22.48 – 22.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative Polycomb group protein ASXL3 is a protein that in humans is encoded by the ASXL3 gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141431 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045215 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Additional sex combs like 3 (Drosophila)".

Further reading

  • Fisher CL, Randazzo F, Humphries RK, Brock HW (March 2006). "Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family". Gene. 369: 109–18. doi:10.1016/j.gene.2005.10.033. PMID 16412590.
  • Katoh M, Katoh M (June 2004). "Identification and characterization of ASXL3 gene in silico". International Journal of Oncology. 24 (6): 1617–22. PMID 15138607.


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