BCL6B

Protein-coding gene in the species Homo sapiens
BCL6B
Identifiers
AliasesBCL6B, BAZF, ZBTB28, ZNF62, B-cell CLL/lymphoma 6B, B cell CLL/lymphoma 6B, transcription repressor, BCL6B transcription repressor
External IDsOMIM: 608992; MGI: 1278332; HomoloGene: 7243; GeneCards: BCL6B; OMA:BCL6B - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for BCL6B
Genomic location for BCL6B
Band17p13.1Start7,023,050 bp[1]
End7,030,290 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for BCL6B
Genomic location for BCL6B
Band11|11 B3Start70,114,954 bp[2]
End70,120,624 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • upper lobe of left lung

  • apex of heart

  • right lung

  • gonad

  • gallbladder

  • subcutaneous adipose tissue

  • tendon of biceps brachii

  • left ventricle

  • lower lobe of lung

  • left lobe of thyroid gland
Top expressed in
  • glomerulus

  • left lung lobe

  • atrium

  • renal vein

  • glomerular capillary

  • aortic valve

  • ascending aorta

  • endocardial cushion

  • vasa recta

  • endothelial cell of lymphatic vessel
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • protein binding
Cellular component
  • nucleus
Biological process
  • negative regulation of transcription by RNA polymerase II
  • type 2 immune response
  • regulation of cell population proliferation
  • regulation of inflammatory response
  • regulation of cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

255877

12029

Ensembl

ENSG00000161940

ENSMUSG00000000317

UniProt

Q8N143

O88282

RefSeq (mRNA)

NM_181844

NM_007528

RefSeq (protein)

NP_862827
NP_862827.1

NP_031554

Location (UCSC)Chr 17: 7.02 – 7.03 MbChr 11: 70.11 – 70.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

B-cell CLL/lymphoma 6 member B protein is a protein that in humans is encoded by the BCL6B gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161940 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000317 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okabe S, Fukuda T, Ishibashi K, Kojima S, Okada S, Hatano M, Ebara M, Saisho H, Tokuhisa T (Jul 1998). "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor". Molecular and Cellular Biology. 18 (7): 4235–44. doi:10.1128/mcb.18.7.4235. PMC 109007. PMID 9632807.
  6. ^ "Entrez Gene: BCL6B B-cell CLL/lymphoma 6, member B (zinc finger protein)".

Further reading

  • Sakashita C, Fukuda T, Okabe S, Kobayashi H, Hirosawa S, Tokuhisa T, Miyasaka N, Miura O, Miki T (Mar 2002). "Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene". Biochemical and Biophysical Research Communications. 291 (3): 567–73. doi:10.1006/bbrc.2002.6481. PMID 11855826.
  • Fitzgibbon J, Neat MJ, Jones L, Foot N, Lister TA, Gupta RK (2000). "Assignment of B-cell lymphoma 6, member B (zinc finger protein) gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 218–9. doi:10.1159/000015617. PMID 10965127. S2CID 28546419.
  • Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Nov 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9563–7. Bibcode:1991PNAS...88.9563B. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
  • Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Aug 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.


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