BTBD14B

Protein-coding gene in the species Homo sapiens
NACC1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3GA1, 4U2N

Identifiers
AliasesNACC1, BEND8, BTBD14B, BTBD30, NAC-1, NAC1, nucleus accumbens associated 1, NECFM
External IDsOMIM: 610672; MGI: 1914080; HomoloGene: 12042; GeneCards: NACC1; OMA:NACC1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NACC1
Genomic location for NACC1
Band19p13.13Start13,116,862 bp[1]
End13,141,147 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NACC1
Genomic location for NACC1
Band8 C3|8 41.02 cMStart85,397,108 bp[2]
End85,414,531 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • nasal epithelium

  • skin of arm

  • stromal cell of endometrium

  • myocardium of left ventricle

  • prefrontal cortex

  • amygdala

  • anterior cingulate cortex

  • buccal mucosa cell

  • decidua
Top expressed in
  • tail of embryo

  • genital tubercle

  • epiblast

  • zygote

  • ventricular zone

  • pyloric antrum

  • yolk sac

  • dentate gyrus of hippocampal formation granule cell

  • crypt of lieberkuhn of small intestine

  • superior frontal gyrus
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

112939

66830

Ensembl

ENSG00000160877

ENSMUSG00000001910

UniProt

Q96RE7

Q7TSZ8

RefSeq (mRNA)

NM_052876

NM_025788

RefSeq (protein)

NP_443108

NP_080064

Location (UCSC)Chr 19: 13.12 – 13.14 MbChr 8: 85.4 – 85.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleus accumbens-associated protein 1 is a protein that in humans is encoded by the NACC1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160877 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001910 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: BTBD14B BTB (POZ) domain containing 14B".

l

  • Human NACC1 genome location and NACC1 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleus accumbens-associated protein 1 (BTBD14B)

Further reading

  • Nakayama K, Nakayama N, Wang TL, Shih IeM (2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Res. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.
  • Davidson B, Berner A, Trope' CG, et al. (2007). "Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions". Hum. Pathol. 38 (7): 1030–6. doi:10.1016/j.humpath.2006.12.009. PMID 17391728.
  • Nakayama K, Nakayama N, Davidson B, et al. (2007). "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival". Proc. Natl. Acad. Sci. U.S.A. 103 (49): 18739–44. doi:10.1073/pnas.0604083103. PMC 1693732. PMID 17130457.
  • Korutla L, Wang PJ, Mackler SA (2005). "The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures". J. Neurochem. 94 (3): 786–93. doi:10.1111/j.1471-4159.2005.03206.x. PMID 16033423. S2CID 42787411.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Korutla L, Wang PJ, Lewis DM, et al. (2002). "Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1". Neuroscience. 110 (3): 421–9. doi:10.1016/S0306-4522(01)00518-8. PMID 11906783. S2CID 13388723.


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