CABYR

Protein-coding gene in the species Homo sapiens
CABYR
Identifiers
AliasesCABYR, CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDsOMIM: 612135; MGI: 1918382; HomoloGene: 49299; GeneCards: CABYR; OMA:CABYR - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for CABYR
Genomic location for CABYR
Band18q11.2Start24,138,987 bp[1]
End24,161,600 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CABYR
Genomic location for CABYR
Band18|18 A1Start12,873,379 bp[2]
End12,888,317 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • gonad

  • oocyte

  • right uterine tube

  • secondary oocyte

  • anterior pituitary

  • anterior cingulate cortex

  • testicle
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • primary visual cortex

  • ascending aorta

  • superior frontal gyrus

  • aortic valve

  • dentate gyrus of hippocampal formation granule cell

  • embryo

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SH3 domain binding
  • enzyme binding
  • calcium ion binding
  • protein binding
  • protein domain specific binding
  • metal ion binding
  • protein heterodimerization activity
Cellular component
  • cytoplasm
  • sperm principal piece
  • cell projection
  • motile cilium
  • cilium
  • sperm fibrous sheath
  • cytoskeleton
  • nucleus
  • sperm end piece
  • cytosol
  • extracellular region
Biological process
  • sperm capacitation
  • epithelial cilium movement involved in extracellular fluid movement
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26256

71132

Ensembl

ENSG00000154040

ENSMUSG00000024430

UniProt

O75952

Q9D424

RefSeq (mRNA)
NM_001308231
NM_012189
NM_138643
NM_138644
NM_153768

NM_153769
NM_153770

NM_001042418
NM_001042419
NM_001042420
NM_027687
NM_181731

RefSeq (protein)
NP_001295160
NP_036321
NP_619584
NP_619585
NP_722452

NP_722453
NP_722454
NP_001295160.1

NP_001035883
NP_001035884
NP_001035885
NP_081963
NP_859420

Location (UCSC)Chr 18: 24.14 – 24.16 MbChr 18: 12.87 – 12.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.[5][6][7][8]

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154040 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024430 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818.
  6. ^ Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841.
  7. ^ Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264.
  8. ^ a b "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

Further reading

  • Fouquet JP; Kann ML (1995). "The cytoskeleton of mammalian spermatozoa". Biol. Cell. 81 (2): 89–93. doi:10.1016/S0248-4900(94)80001-4. PMID 7849610. S2CID 39352537.
  • Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50. doi:10.1016/S0165-0378(01)00103-6. PMID 11730911.
  • Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID 15752768.


  • v
  • t
  • e