CBX8

Protein-coding gene in the species Homo sapiens

CBX8

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3I91, 5EQ0, 2N4Q

Identifiers

Aliases

CBX8, PC3, RC1, chromobox 8

External IDs

OMIM: 617354; MGI: 1353589; HomoloGene: 32199; GeneCards: CBX8; OMA:CBX8 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.3	Start	79,792,132 bp^[1]
Band	17q25.3	End	79,801,683 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	118,927,131 bp^[2]
Band	11\|11 E2	End	118,931,795 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

gonad

stromal cell of endometrium

right testis

ganglionic eminence

left testis

ventricular zone

apex of heart

granulocyte

right lobe of liver

Top expressed in

granulocyte

respiratory epithelium

olfactory epithelium

Rostral migratory stream

neural layer of retina

thymus

proximal tubule

right kidney

yolk sac

ganglionic eminence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	methylated histone binding protein binding single-stranded RNA binding ubiquitin-protein transferase activator activity
Cellular component	ubiquitin ligase complex nucleoplasm heterochromatin PRC1 complex PcG protein complex nucleus
Biological process	positive regulation of collagen biosynthetic process regulation of transcription, DNA-templated positive regulation of DNA repair negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of cell population proliferation regulation of catalytic activity histone ubiquitination cellular response to hydrogen peroxide chromatin organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57332


30951

Ensembl


ENSG00000141570


ENSMUSG00000025578

UniProt


Q9HC52


Q9QXV1

RefSeq (mRNA)


NM_020649


NM_013926

RefSeq (protein)


NP_065700


NP_038954

Location (UCSC)

Chr 17: 79.79 – 79.8 Mb

Chr 11: 118.93 – 118.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.^[5]^[6]

Interactions

CBX8 has been shown to interact with RING1^[7] and MLLT1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025578 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
^ "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
^ Bárdos JI, Saurin A J, Tissot C, Duprez E, Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
^ García-Cuéllar MP, Zilles O, Schreiner S A, Birke M, Winkler T H, Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

External links

Human CBX8 genome location and CBX8 gene details page in the UCSC Genome Browser.

García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343. S2CID 25138105.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Dietrich N, Bracken AP, Trinh E, et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMC 1829390. PMID 17332741.