CCT6B

Protein-coding gene in the species Homo sapiens
CCT6B
Identifiers
AliasesCCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDsOMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CCT6B
Genomic location for CCT6B
Band17q12Start34,927,859 bp[1]
End34,981,078 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CCT6B
Genomic location for CCT6B
Band11|11 CStart82,610,076 bp[2]
End82,655,147 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • testicle

  • gonad

  • olfactory zone of nasal mucosa

  • Achilles tendon

  • gastrocnemius muscle

  • palpebral conjunctiva

  • gastric mucosa
Top expressed in
  • spermatid

  • spermatocyte

  • seminiferous tubule

  • blastocyst

  • embryo

  • Ileal epithelium

  • embryo

  • morula

  • morula

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ATP binding
  • protein folding chaperone activity
  • unfolded protein binding
Cellular component
  • cytoplasm
  • cytosol
  • chaperonin-containing T-complex
Biological process
  • toxin transport
  • protein folding
  • chaperone-mediated protein complex assembly
  • spermatogenesis
  • protein transport
  • 'de novo' protein folding
  • chaperone-mediated protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10693

12467

Ensembl

ENSG00000132141

ENSMUSG00000020698

UniProt

Q92526

Q61390

RefSeq (mRNA)

NM_001193529
NM_001193530
NM_006584

NM_001291242
NM_009839

RefSeq (protein)

NP_001180458
NP_001180459
NP_006575

NP_001278171
NP_033969

Location (UCSC)Chr 17: 34.93 – 34.98 MbChr 11: 82.61 – 82.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.[5][6][7]

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132141 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020698 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.
  6. ^ Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858. S2CID 1972107.
  7. ^ a b "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

Further reading

  • Stirling PC, Cuéllar J, Alfaro GA, et al. (2006). "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates". J. Biol. Chem. 281 (11): 7012–21. doi:10.1074/jbc.M513235200. PMID 16415341.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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