CCT7

Protein-coding gene in the species Homo sapiens

CCT7
Identifiers
AliasesCCT7, CCTETA, CCTH, NIP7-1, TCP1ETA, chaperonin containing TCP1 subunit 7
External IDsOMIM: 605140; MGI: 107184; HomoloGene: 4694; GeneCards: CCT7; OMA:CCT7 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CCT7
Genomic location for CCT7
Band2p13.2Start73,233,420 bp[1]
End73,253,021 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CCT7
Genomic location for CCT7
Band6|6 C3Start85,428,496 bp[2]
End85,445,457 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • islet of Langerhans

  • right testis

  • left testis

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • muscle of thigh

  • gastrocnemius muscle
Top expressed in
  • primitive streak

  • renal corpuscle

  • medullary collecting duct

  • medial ganglionic eminence

  • hair follicle

  • endothelial cell of lymphatic vessel

  • ureter

  • ascending aorta

  • epiblast

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleotide binding
  • identical protein binding
  • ATP binding
  • protein folding chaperone activity
  • unfolded protein binding
Cellular component
  • cytoplasm
  • mitochondrion
  • cytosol
  • cell body
  • zona pellucida receptor complex
  • microtubule
  • extracellular exosome
  • chaperonin-containing T-complex
Biological process
  • positive regulation of protein localization to Cajal body
  • positive regulation of telomerase RNA localization to Cajal body
  • positive regulation of telomere maintenance via telomerase
  • toxin transport
  • positive regulation of establishment of protein localization to telomere
  • protein folding
  • binding of sperm to zona pellucida
  • protein stabilization
  • 'de novo' protein folding
  • chaperone-mediated protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10574

12468

Ensembl

ENSG00000135624

ENSMUSG00000030007

UniProt

Q99832

P80313

RefSeq (mRNA)

NM_001009570
NM_001166284
NM_001166285
NM_006429

NM_007638

RefSeq (protein)

NP_001009570
NP_001159756
NP_001159757
NP_006420

NP_031664

Location (UCSC)Chr 2: 73.23 – 73.25 MbChr 6: 85.43 – 85.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.[5][6]

Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.[6]

Interactions

CCT7 has been shown to interact with PPP4C.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135624 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030007 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
  6. ^ a b "Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)".
  7. ^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  8. ^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading

  • Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. Bibcode:1994CBio....4...89K. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR (Nov 1996). "Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits". Electrophoresis. 17 (11): 1720–7. doi:10.1002/elps.1150171109. PMID 8982604. S2CID 11257092.{{cite journal}}: CS1 maint: date and year (link)
  • Liou AK, Willison KR (Jul 1997). "Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes". The EMBO Journal. 16 (14): 4311–6. doi:10.1093/emboj/16.14.4311. PMC 1170057. PMID 9250675.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Yokota S, Yanagi H, Yura T, Kubota H (Sep 2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". European Journal of Biochemistry. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.{{cite journal}}: CS1 maint: date and year (link)
  • Hanafy KA, Martin E, Murad F (Nov 2004). "CCTeta, a novel soluble guanylyl cyclase-interacting protein". The Journal of Biological Chemistry. 279 (45): 46946–53. doi:10.1074/jbc.M404134200. PMID 15347653.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.


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