Protein-coding gene in the species Homo sapiens
| CDK5RAP3 |
|---|
|
| Identifiers |
|---|
| Aliases | CDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3 |
|---|
| External IDs | OMIM: 608202; MGI: 1933126; HomoloGene: 12718; GeneCards: CDK5RAP3; OMA:CDK5RAP3 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 17 (human)[1] |
|---|
| | Band | 17q21.32 | Start | 47,967,810 bp[1] |
|---|
| End | 47,981,781 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 11 (mouse)[2] |
|---|
| | Band | 11|11 D | Start | 96,798,252 bp[2] |
|---|
| End | 96,807,322 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - pituitary gland
- right uterine tube
- anterior pituitary
- right lobe of thyroid gland
- body of pancreas
- left lobe of thyroid gland
- spleen
- right hemisphere of cerebellum
- left testis
- right testis
|
| | Top expressed in | - lacrimal gland
- yolk sac
- molar
- parotid gland
- left lobe of liver
- seminal vesicula
- spermatocyte
- spermatid
- islet of Langerhans
- primitive streak
|
| | More reference expression data |
|
|---|
| BioGPS |  | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - MDM2/MDM4 family protein binding
- NF-kappaB binding
- mitogen-activated protein kinase binding
- protein binding
- ubiquitin-like protein ligase binding
- protein kinase binding
- cyclin binding
| | Cellular component | - cytoplasm
- centrosome
- membrane
- microtubule organizing center
- nucleolus
- microtubule
- cytoskeleton
- endomembrane system
- nucleus
- cytosol
- protein-containing complex
| | Biological process | - negative regulation of protein phosphorylation
- regulation of neuron differentiation
- protein ufmylation
- positive regulation of signal transduction by p53 class mediator
- regulation of phosphatase activity
- endoplasmic reticulum unfolded protein response
- mitotic G2/M transition checkpoint
- brain development
- apoptotic nuclear changes
- negative regulation of MAP kinase activity
- positive regulation of ubiquitin-dependent protein catabolic process
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- negative regulation of protein serine/threonine kinase activity
- cell population proliferation
- mitotic G2 DNA damage checkpoint signaling
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of protein ubiquitination
- positive regulation of transcription by RNA polymerase II
- positive regulation of protein localization to nucleus
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of mitotic cell cycle
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | NM_001278197
NM_001278198
NM_001278216
NM_001278217
NM_025197
|
|---|
NM_176095
NM_176096 |
| |
|---|
NM_030248
NM_001308183
NM_001363255
NM_001363256 |
|
|---|
| RefSeq (protein) | |
|---|
NP_001265126
NP_001265127
NP_001265145
NP_001265146
NP_788276 |
| |
|---|
NP_001295112
NP_084524
NP_001350184
NP_001350185 |
|
|---|
| Location (UCSC) | Chr 17: 47.97 – 47.98 Mb | Chr 11: 96.8 – 96.81 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.[5][6]
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108465 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018669 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
- ^ a b "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
- Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
- Chen J, Liu B, Liu Y, et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Xie YH, He XH, Tang YT, et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517. S2CID 22264922.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Cen H, Zheng S, Fang YM, et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer". World J. Gastroenterol. 10 (21): 3122–6. doi:10.3748/wjg.v10.i21.3122. PMC 4611254. PMID 15457556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
- Yin X, Warner DR, Roberts EA, et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53". Int. J. Mol. Med. 16 (2): 251–6. doi:10.3892/ijmm.16.2.251. PMID 16012757.
- Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMC 1360699. PMID 16173922.
- Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation". Int. J. Oncol. 28 (1): 191–4. doi:10.3892/ijo.28.1.191. PMID 16327995.
- Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677. S2CID 25119660.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma". Int. J. Biol. Markers. 22 (2): 108–13. doi:10.5301/jbm.2008.3142. PMID 17549666.
- Wang J, An H, Mayo MW, et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB". Cancer Cell. 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.
External links
