CHMP2A

Protein-coding gene in the species Homo sapiens

CHMP2A
Identifiers
AliasesCHMP2A, BC-2, BC2, CHMP2, VPS2, VPS2A, charged multivesicular body protein 2A
External IDsOMIM: 610893; MGI: 1916203; HomoloGene: 6382; GeneCards: CHMP2A; OMA:CHMP2A - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CHMP2A
Genomic location for CHMP2A
Band19q13.43Start58,551,452 bp[1]
End58,555,105 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CHMP2A
Genomic location for CHMP2A
Band7 A1|7Start12,765,937 bp[2]
End12,768,734 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • oral cavity

  • olfactory zone of nasal mucosa

  • skin of leg

  • apex of heart

  • gastric mucosa
Top expressed in
  • corneal stroma

  • saccule

  • seminal vesicula

  • superior surface of tongue

  • arcuate nucleus

  • olfactory epithelium

  • neural layer of retina

  • left colon

  • otic vesicle

  • skin of external ear
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein domain specific binding
  • phosphatidylcholine binding
  • protein binding
Cellular component
  • cytosol
  • endosome
  • membrane
  • late endosome membrane
  • membrane coat
  • extracellular exosome
  • ESCRT III complex
  • nuclear envelope
  • chromatin
  • multivesicular body
Biological process
  • regulation of centrosome duplication
  • protein polymerization
  • viral budding via host ESCRT complex
  • protein heterooligomerization
  • nucleus organization
  • viral life cycle
  • establishment of protein localization
  • negative regulation of centriole elongation
  • membrane invagination
  • multivesicular body assembly
  • negative regulation of cell death
  • regulation of mitotic spindle assembly
  • endosomal transport
  • transport
  • protein transport
  • positive regulation of exosomal secretion
  • septum digestion after cytokinesis
  • mitotic metaphase plate congression
  • protein homooligomerization
  • vacuolar transport
  • regulation of viral process
  • ESCRT III complex disassembly
  • nuclear membrane reassembly
  • exit from mitosis
  • macroautophagy
  • endosome transport via multivesicular body sorting pathway
  • late endosome to vacuole transport
  • midbody abscission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27243

68953

Ensembl

ENSG00000130724

ENSMUSG00000033916

UniProt

O43633

Q9DB34

RefSeq (mRNA)

NM_014453
NM_198426

NM_026885
NM_001360730
NM_001360731
NM_001360733

RefSeq (protein)

NP_055268
NP_940818

NP_081161
NP_001347659
NP_001347660
NP_001347662

Location (UCSC)Chr 19: 58.55 – 58.56 MbChr 7: 12.77 – 12.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene.[5][6][7] 

It is a reference gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130724 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033916 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fujita H, Umezuki Y, Imamura K, Ishikawa D, Uchimura S, Nara A, Yoshimori T, Hayashizaki Y, Kawai J, Ishidoh K, Tanaka Y, Himeno M (Jun 2004). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J Cell Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323. S2CID 726248.
  6. ^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
  7. ^ "Entrez Gene: CHMP2A chromatin modifying protein 2A".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.


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