CHMP6

Protein-coding gene in the species Homo sapiens
CHMP6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2K3W, 3HTU

Identifiers
AliasesCHMP6, VPS20, charged multivesicular body protein 6
External IDsOMIM: 610901; MGI: 3583942; HomoloGene: 11607; GeneCards: CHMP6; OMA:CHMP6 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CHMP6
Genomic location for CHMP6
Band17q25.3Start80,991,598 bp[1]
End81,009,517 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CHMP6
Genomic location for CHMP6
Band11|11 E2Start119,804,267 bp[2]
End119,810,374 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • gastrocnemius muscle

  • muscle of thigh

  • mucosa of transverse colon

  • monocyte

  • granulocyte

  • right lobe of liver

  • sural nerve

  • stromal cell of endometrium

  • ectocervix
Top expressed in
  • right kidney

  • saccule

  • otic vesicle

  • yolk sac

  • otic placode

  • spermatocyte

  • proximal tubule

  • duodenum

  • human kidney

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein N-terminus binding
  • protein binding
  • protein-containing complex binding
Cellular component
  • ESCRT III complex
  • cytosol
  • endosome
  • membrane
  • late endosome membrane
  • endosome membrane
  • extracellular exosome
  • endomembrane system
Biological process
  • viral life cycle
  • nucleus organization
  • regulation of exosomal secretion
  • multivesicular body assembly
  • ESCRT III complex assembly
  • endosomal transport
  • protein transport
  • septum digestion after cytokinesis
  • mitotic metaphase plate congression
  • vacuolar transport
  • macroautophagy
  • negative regulation of epidermal growth factor-activated receptor activity
  • transport
  • regulation of protein catabolic process
  • midbody abscission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79643

208092

Ensembl

ENSG00000176108

ENSMUSG00000025371

UniProt

Q96FZ7

P0C0A3

RefSeq (mRNA)

NM_024591

NM_001085498

RefSeq (protein)

NP_078867

NP_001078967

Location (UCSC)Chr 17: 80.99 – 81.01 MbChr 11: 119.8 – 119.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.[5][6][7] It is one of charged multivesicular body proteins and a part of endosomal sorting complexes required for transport-III (ESCRT-III) complex.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176108 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025371 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
  6. ^ Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T, Uchiyama Y, Maki M (Mar 2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
  7. ^ "CHMP6 charged multivesicular body protein 6 [ Homo sapiens (human) ]".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
  • Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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