CIRBP

Protein-coding gene in humans

CIRBP

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1X5S

Identifiers

Aliases

CIRBP, CIRP, cold inducible RNA binding protein

External IDs

OMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	1,259,384 bp^[1]
Band	19p13.3	End	1,274,880 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C1\|10 39.72 cM	Start	80,165,985 bp^[2]
Band	10 C1\|10 39.72 cM	End	80,172,786 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tibia

corpus epididymis

caput epididymis

parietal pleura

germinal epithelium

right hemisphere of cerebellum

right uterine tube

anterior pituitary

middle temporal gyrus

left ovary

Top expressed in

neural layer of retina

cerebellar cortex

molar

ventricular zone

spermatocyte

superior frontal gyrus

primary visual cortex

dorsomedial hypothalamic nucleus

paraventricular nucleus of hypothalamus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	translation repressor activity nucleic acid binding protein binding small ribosomal subunit rRNA binding mRNA 3'-UTR binding RNA binding poly(U) RNA binding
Cellular component	cytoplasm cytoplasmic stress granule nucleolus nucleus nucleoplasm spliceosomal complex ribonucleoprotein complex
Biological process	stress granule assembly response to cold mRNA stabilization response to UV positive regulation of translation negative regulation of translation positive regulation of mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1153


12696

Ensembl


ENSG00000099622


ENSMUSG00000045193

UniProt


Q14011 Q53XX5


P60824

RefSeq (mRNA)


NM_001280 NM_001300815 NM_001300829


NM_007705

RefSeq (protein)


NP_001271 NP_001287744 NP_001287758 NP_001271.1

NP_031731 NP_001366350 NP_001366351 NP_001366352 NP_001366353
NP_001366354

Location (UCSC)

Chr 19: 1.26 – 1.27 Mb

Chr 10: 80.17 – 80.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.^[5]^[6]^[7] The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099622 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, Fujita J (Feb 1998). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–20. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.
^ Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (Jun 1997). "A Glycine-rich RNA-binding Protein Mediating Cold-inducible Suppression of Mammalian Cell Growth". J Cell Biol. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845. PMID 9151692.
^ "Entrez Gene: CIRBP cold inducible RNA binding protein".

External links

Human CIRBP genome location and CIRBP gene details page in the UCSC Genome Browser.

Sheikh MS, Carrier F, Papathanasiou MA, et al. (1997). "Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein". J. Biol. Chem. 272 (42): 26720–6. doi:10.1074/jbc.272.42.26720. PMID 9334257.
Nishiyama H, Danno S, Kaneko Y, et al. (1998). "Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature". Am. J. Pathol. 152 (1): 289–96. PMC 1858111. PMID 9422546.
Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMC 1084016. PMID 11850402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hamid AA, Mandai M, Fujita J, et al. (2004). "Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma". Int. J. Gynecol. Pathol. 22 (3): 240–7. doi:10.1097/01.PGP.0000070851.25718.EC. PMID 12819390. S2CID 22639276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Wellmann S, Bührer C, Moderegger E, et al. (2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". J. Cell Sci. 117 (Pt 9): 1785–94. doi:10.1242/jcs.01026. PMID 15075239.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.