CLASP2

Protein-coding gene in the species Homo sapiens
CLASP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3WOY

Identifiers
AliasesCLASP2, cytoplasmic linker associated protein 2
External IDsOMIM: 605853; MGI: 1923749; HomoloGene: 24944; GeneCards: CLASP2; OMA:CLASP2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CLASP2
Genomic location for CLASP2
Band3p22.3Start33,496,245 bp[1]
End33,718,356 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CLASP2
Genomic location for CLASP2
Band9|9 F3Start113,741,473 bp[2]
End113,919,682 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • paraflocculus of cerebellum

  • middle frontal gyrus

  • Brodmann area 10

  • frontal pole

  • endothelial cell

  • lateral nuclear group of thalamus

  • ganglionic eminence

  • subthalamic nucleus

  • inferior ganglion of vagus nerve
Top expressed in
  • lateral geniculate nucleus

  • inferior colliculus

  • medial geniculate nucleus

  • pineal gland

  • mammillary body

  • superior colliculus

  • medial dorsal nucleus

  • cerebellar vermis

  • lobe of cerebellum

  • globus pallidus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein tyrosine kinase binding
  • dystroglycan binding
  • microtubule binding
  • microtubule plus-end binding
  • actin filament binding
  • protein binding
  • kinetochore binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • cell projection
  • kinetochore microtubule
  • membrane
  • focal adhesion
  • plasma membrane
  • axonal growth cone
  • spindle
  • microtubule organizing center
  • chromosome
  • ruffle membrane
  • trans-Golgi network
  • cell cortex
  • cell leading edge
  • cortical microtubule plus-end
  • cytoplasmic microtubule
  • mitotic spindle
  • basal cortex
  • microtubule
  • chromosome, centromeric region
  • cytoskeleton
  • kinetochore
  • cytosol
Biological process
  • vesicle targeting
  • regulation of actin cytoskeleton organization
  • regulation of axon extension
  • Golgi organization
  • mitotic spindle organization
  • regulation of epithelial to mesenchymal transition
  • positive regulation of epithelial cell migration
  • exit from mitosis
  • cell division
  • establishment or maintenance of cell polarity
  • positive regulation of extracellular matrix disassembly
  • positive regulation of basement membrane assembly involved in embryonic body morphogenesis
  • negative regulation of microtubule depolymerization
  • microtubule anchoring
  • regulation of microtubule-based process
  • regulation of microtubule polymerization
  • regulation of microtubule polymerization or depolymerization
  • negative regulation of wound healing, spreading of epidermal cells
  • cell cycle
  • positive regulation of exocytosis
  • negative regulation of stress fiber assembly
  • microtubule organizing center organization
  • negative regulation of focal adhesion assembly
  • regulation of gastrulation
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • platelet-derived growth factor receptor-beta signaling pathway
  • sister chromatid cohesion
  • protein localization to plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23122

76499

Ensembl

ENSG00000163539

ENSMUSG00000033392

UniProt

O75122

Q8BRT1

RefSeq (mRNA)
NM_001207044
NM_015097
NM_001365627
NM_001365628
NM_001365629

NM_001365630
NM_001365631
NM_001365632
NM_001365633
NM_001365634
NM_001375694
NM_001375697
NM_001375700
NM_001375701
NM_001375703
NM_001375705
NM_001375713
NM_001375715
NM_001375716
NM_001375718
NM_001375720

NM_001081960
NM_001114347
NM_001286599
NM_001286600
NM_001286601

NM_001286602
NM_001286603
NM_029633

RefSeq (protein)
NP_001193973
NP_055912
NP_001352556
NP_001352557
NP_001352558

NP_001352559
NP_001352560
NP_001352561
NP_001352562
NP_001352563
NP_001362623
NP_001362626
NP_001362629
NP_001362630
NP_001362632
NP_001362634
NP_001362642
NP_001362644
NP_001362645
NP_001362647
NP_001362649

NP_001075429
NP_001107819
NP_001273528
NP_001273529
NP_001273530

NP_001273531
NP_001273532
NP_083909

Location (UCSC)Chr 3: 33.5 – 33.72 MbChr 9: 113.74 – 113.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163539 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033392 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

External links

Further reading

  • Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
  • Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329. S2CID 14443149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. hdl:10216/53832. PMID 12837247. S2CID 13936836.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance". Neuron. 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
  • Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
  • Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
  • Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869. S2CID 33744175.
  • Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function" (PDF). Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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