CNOT3

Protein-coding gene in the species Homo sapiens
CNOT3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4C0D, 4C0G, 5FU6, 5FU7

Identifiers
AliasesCNOT3, LENG2, NOT3, NOT3H, CCR4-NOT transcription complex subunit 3, IDDSADF
External IDsOMIM: 604910; MGI: 2385261; HomoloGene: 133900; GeneCards: CNOT3; OMA:CNOT3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CNOT3
Genomic location for CNOT3
Band19q13.42Start54,137,749 bp[1]
End54,155,681 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CNOT3
Genomic location for CNOT3
Band7|7 A1Start3,645,268 bp[2]
End3,661,109 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • pituitary gland

  • granulocyte

  • right uterine tube

  • anterior pituitary

  • right hemisphere of cerebellum

  • ventricular zone

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • blood
Top expressed in
  • zygote

  • genital tubercle

  • tail of embryo

  • granulocyte

  • ventricular zone

  • yolk sac

  • neural layer of retina

  • lip

  • hand

  • Rostral migratory stream
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • CCR4-NOT complex
  • cytosol
  • P-body
  • nucleus
  • CCR4-NOT core complex
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • multicellular organism development
  • gene silencing
  • negative regulation of translation
  • regulation of stem cell population maintenance
  • regulation of transcription, DNA-templated
  • trophectodermal cell differentiation
  • regulation of translation
  • transcription, DNA-templated
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4849

232791

Ensembl
ENSG00000088038
ENSG00000277600
ENSG00000277114
ENSG00000274616
ENSG00000275979

ENSG00000277615
ENSG00000276082
ENSG00000274176
ENSG00000274941
ENSG00000273943

ENSMUSG00000035632

UniProt

O75175

Q8K0V4

RefSeq (mRNA)

NM_014516

NM_146176

RefSeq (protein)

NP_055331

NP_666288

Location (UCSC)Chr 19: 54.14 – 54.16 MbChr 7: 3.65 – 3.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene.[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT3 has been shown to interact with CNOT8.[5]

References

  1. ^ a b c ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 GRCh38: Ensembl release 89: ENSG00000088038, ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035632 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  6. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  7. ^ "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

Further reading

  • Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
  • Aoki T, Okada N, Wakamatsu T, Tamura TA (2002). "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3". Biochem. Biophys. Res. Commun. 296 (5): 1097–103. doi:10.1016/S0006-291X(02)02031-4. PMID 12207886.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.
  • v
  • t
  • e