CNOT4

Protein-coding gene in the species Homo sapiens

CNOT4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1E4U, 1UR6

Identifiers
AliasesCNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDsOMIM: 604911; MGI: 1859026; HomoloGene: 40870; GeneCards: CNOT4; OMA:CNOT4 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CNOT4
Genomic location for CNOT4
Band7q33Start135,361,795 bp[1]
End135,510,127 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CNOT4
Genomic location for CNOT4
Band6|6 B1Start34,999,000 bp[2]
End35,110,659 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • Achilles tendon

  • testicle

  • gastrocnemius muscle

  • parietal pleura

  • corpus callosum

  • internal globus pallidus

  • sural nerve

  • endothelial cell

  • muscle of thigh
Top expressed in
  • genital tubercle

  • Rostral migratory stream

  • tail of embryo

  • zygote

  • saccule

  • primary oocyte

  • secondary oocyte

  • otic placode

  • fossa

  • otic vesicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • protein binding
  • nucleic acid binding
  • metal ion binding
  • transferase activity
  • RNA binding
Cellular component
  • cytosol
  • cytoplasm
  • CCR4-NOT complex
  • nucleus
Biological process
  • protein ubiquitination
  • nuclear-transcribed mRNA poly(A) tail shortening
  • protein autoubiquitination
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • ubiquitin-dependent protein catabolic process
  • regulation of megakaryocyte differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4850

53621

Ensembl

ENSG00000080802

ENSMUSG00000038784

UniProt

O95628

Q8BT14

RefSeq (mRNA)
NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850

NM_013316
NM_001393370
NM_001393371
NM_001393372
NM_001393373
NM_001393374
NM_001393375

NM_001164411
NM_001164412
NM_001164413
NM_001164414
NM_016877

RefSeq (protein)
NP_001008226
NP_001177776
NP_001177777
NP_001177778
NP_001177779

NP_037448

NP_001157883
NP_001157884
NP_001157885
NP_001157886
NP_058573

Location (UCSC)Chr 7: 135.36 – 135.51 MbChr 6: 35 – 35.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080802 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038784 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCR4-NOT transcription complex, subunit 4".
  6. ^ "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

Further reading

  • Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038. S2CID 25618632.
  • Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
  • Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits" (PDF). The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
  • Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
  • Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
  • Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
  • Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
  • Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
  • Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e