CRB3

Protein-coding gene in the species Homo sapiens
CRB3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5I7Z

Identifiers
AliasesCRB3, crumbs 3, cell polarity complex component, crumbs cell polarity complex component 3
External IDsOMIM: 609737; MGI: 2670904; HomoloGene: 138188; GeneCards: CRB3; OMA:CRB3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CRB3
Genomic location for CRB3
Band19p13.3Start6,463,777 bp[1]
End6,467,221 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CRB3
Genomic location for CRB3
Band17|17 DStart57,366,105 bp[2]
End57,372,918 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of pharynx

  • mucosa of transverse colon

  • vena cava

  • nasal epithelium

  • skin of arm

  • body of pancreas

  • parotid gland

  • body of tongue

  • pylorus

  • skin of leg
Top expressed in
  • yolk sac

  • secondary oocyte

  • zygote

  • duodenum

  • right kidney

  • stomach

  • morula

  • morula

  • pyloric antrum

  • mucous cell of stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • SH3 domain binding
  • protein binding
  • protein domain specific binding
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • apical part of cell
  • extracellular exosome
  • apical plasma membrane
  • membrane
  • bicellular tight junction
  • protein-containing complex
Biological process
  • protein localization to plasma membrane
  • bicellular tight junction assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92359

224912

Ensembl

ENSG00000130545

ENSMUSG00000044279

UniProt

Q9BUF7

Q8QZT4

RefSeq (mRNA)

NM_139161
NM_174881
NM_174882

NM_177638
NM_001347408
NM_001359813
NM_001359814

RefSeq (protein)

NP_631900
NP_777377
NP_777378

NP_001334337
NP_808306
NP_001346742
NP_001346743

Location (UCSC)Chr 19: 6.46 – 6.47 MbChr 17: 57.37 – 57.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.[5]

Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130545 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044279 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CRB3 crumbs homolog 3 (Drosophila)".

Further reading

  • Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". The Journal of Biological Chemistry. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
  • Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
  • Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". Journal of Cell Science. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
  • Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Molecular Biology of the Cell. 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMC 363137. PMID 14718572.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells". Journal of Cell Science. 118 (Pt 13): 2859–69. doi:10.1242/jcs.02412. PMID 15976445.
  • Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology. 178 (3): 387–98. doi:10.1083/jcb.200609096. PMC 2064851. PMID 17646395.
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