CRLF3

Protein-coding gene in the species Homo sapiens

CRLF3
Identifiers
AliasesCRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDsOMIM: 614853; MGI: 1860086; HomoloGene: 9327; GeneCards: CRLF3; OMA:CRLF3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CRLF3
Genomic location for CRLF3
Band17q11.2Start30,769,388 bp[1]
End30,824,692 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CRLF3
Genomic location for CRLF3
Band11 B5|11 47.43 cMStart79,937,319 bp[2]
End79,971,817 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trabecular bone

  • mononuclear cell

  • monocyte

  • bone marrow

  • blood

  • lymph node

  • epithelium of nasopharynx

  • thymus

  • bone marrow cells

  • mucosa of sigmoid colon
Top expressed in
  • neural layer of retina

  • granulocyte

  • spleen

  • blood

  • mesenteric lymph nodes

  • thymus

  • tibiofemoral joint

  • fetal liver hematopoietic progenitor cell

  • bone marrow

  • right lung lobe
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
  • DNA binding
Cellular component
  • plasma membrane
  • cytoplasm
  • cytosol
  • nucleus
Biological process
  • negative regulation of cell growth
  • positive regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • positive regulation of receptor signaling pathway via JAK-STAT
  • G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51379

54394

Ensembl

ENSG00000176390

ENSMUSG00000017561

UniProt

Q8IUI8

Q9Z2L7

RefSeq (mRNA)

NM_015986

NM_001277106
NM_018776

RefSeq (protein)

NP_057070

NP_001264035
NP_061246

Location (UCSC)Chr 17: 30.77 – 30.82 MbChr 11: 79.94 – 79.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[5]

Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.[6]

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176390 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017561 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: cytokine receptor-like factor 3".
  6. ^ Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10: 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.
  7. ^ Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12: 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.
  8. ^ Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. Bibcode:2007BMCEE...7..120L. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.

Further reading

  • Visser R, Koelma N, Vijfhuizen L, van der Wielen MJ, Kant SG, Breuning MH, et al. (February 2009). "RNF135 mutations are not present in patients with Sotos syndrome-like features". American Journal of Medical Genetics. Part A. 149A (4): 806–8. doi:10.1002/ajmg.a.32694. PMID 19291764. S2CID 10349510.
  • Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, et al. (May 2008). "Many sequence variants affecting diversity of adult human height". Nature Genetics. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
  • Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, et al. (June 2010). "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature". BMC Medical Genetics. 11: 96. doi:10.1186/1471-2350-11-96. PMC 2894790. PMID 20546612.
  • Yang F, Xu YP, Li J, Duan SS, Fu YJ, Zhang Y, et al. (November 2009). "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression". The International Journal of Biochemistry & Cell Biology. 41 (11): 2240–50. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, et al. (July 2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genetics. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
  • Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
  • Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, et al. (August 2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nature Genetics. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.
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