CTR9

Protein-coding gene in the species Homo sapiens
CTR9
Identifiers
AliasesCTR9, SH2BP1, TSBP, p150, p150TSP, CTR9 homolog, Paf1/RNA polymerase II complex component
External IDsOMIM: 609366; MGI: 109345; HomoloGene: 40668; GeneCards: CTR9; OMA:CTR9 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CTR9
Genomic location for CTR9
Band11p15.4Start10,751,246 bp[1]
End10,801,625 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CTR9
Genomic location for CTR9
Band7 E3|7 57.98 cMStart110,628,158 bp[2]
End110,655,584 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • epithelium of nasopharynx

  • palpebral conjunctiva

  • bronchial epithelial cell

  • germinal epithelium

  • retinal pigment epithelium

  • caput epididymis

  • oral cavity

  • jejunal mucosa

  • tail of epididymis
Top expressed in
  • Rostral migratory stream

  • neural layer of retina

  • spermatocyte

  • transitional epithelium of urinary bladder

  • tail of embryo

  • gastrula

  • uterus

  • spermatid

  • genital tubercle

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II complex binding
  • SH2 domain binding
  • protein binding
Cellular component
  • nuclear speck
  • nucleus
  • nucleoplasm
  • Cdc73/Paf1 complex
Biological process
  • histone monoubiquitination
  • receptor signaling pathway via JAK-STAT
  • negative regulation of mRNA polyadenylation
  • regulation of transcription, DNA-templated
  • histone H3-K4 trimethylation
  • negative regulation of transcription by RNA polymerase II
  • Wnt signaling pathway
  • transcription, DNA-templated
  • stem cell population maintenance
  • interleukin-6-mediated signaling pathway
  • endodermal cell fate commitment
  • positive regulation of histone H3-K4 methylation
  • inner cell mass cell differentiation
  • trophectodermal cell differentiation
  • positive regulation of histone H3-K79 methylation
  • blastocyst growth
  • histone H2B ubiquitination
  • positive regulation of histone H2B ubiquitination
  • cellular response to lipopolysaccharide
  • negative regulation of myeloid cell differentiation
  • regulation of genetic imprinting
  • positive regulation of transcription elongation from RNA polymerase II promoter
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
  • protein ubiquitination
  • histone modification
  • regulation of histone H3-K4 methylation
  • blastocyst hatching
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9646

22083

Ensembl

ENSG00000198730

ENSMUSG00000005609

UniProt

Q6PD62

Q62018

RefSeq (mRNA)

NM_014633
NM_001346279

NM_009431

RefSeq (protein)

NP_001333208
NP_055448

NP_033457

Location (UCSC)Chr 11: 10.75 – 10.8 MbChr 7: 110.63 – 110.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the CTR9 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198730 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005609 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
  6. ^ Malek SN, Yang CH, Earnshaw WC, Kozak CA, Desiderio S (Jul 1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J Biol Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124.
  7. ^ "Entrez Gene: CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

Further reading

  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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