CXXC1

Protein-coding gene in the species Homo sapiens
CXXC1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI

Identifiers
AliasesCXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDsOMIM: 609150; MGI: 1921572; HomoloGene: 32221; GeneCards: CXXC1; OMA:CXXC1 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for CXXC1
Genomic location for CXXC1
Band18q21.1Start50,282,343 bp[1]
End50,287,839 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CXXC1
Genomic location for CXXC1
Band18|18 E2Start74,349,195 bp[2]
End74,354,567 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • body of pancreas

  • right uterine tube

  • pancreatic ductal cell

  • granulocyte

  • right lobe of thyroid gland

  • skin of leg

  • sural nerve

  • skin of abdomen

  • left lobe of thyroid gland
Top expressed in
  • Ileal epithelium

  • tail of embryo

  • genital tubercle

  • neural layer of retina

  • choroid plexus of fourth ventricle

  • lactiferous gland

  • entorhinal cortex

  • perirhinal cortex

  • secondary oocyte

  • otic vesicle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • zinc ion binding
  • protein binding
  • cis-regulatory region sequence-specific DNA binding
  • histone methyltransferase activity (H3-K4 specific)
  • metal ion binding
  • unmethylated CpG binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nuclear matrix
  • nuclear speck
  • nucleus
  • nucleoplasm
  • histone methyltransferase complex
  • cytosol
  • Set1C/COMPASS complex
Biological process
  • positive regulation of transcription, DNA-templated
  • IRE1-mediated unfolded protein response
  • histone H3-K4 methylation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30827

74322

Ensembl

ENSG00000154832

ENSMUSG00000024560

UniProt

Q9P0U4

Q9CWW7

RefSeq (mRNA)

NM_001101654
NM_014593

NM_028868
NM_001378844

RefSeq (protein)

NP_001095124
NP_055408

NP_083144
NP_001365773

Location (UCSC)Chr 18: 50.28 – 50.29 MbChr 18: 74.35 – 74.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.[5][6][7]

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154832 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024560 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
  6. ^ a b Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
  7. ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".
  • Human CXXC1 genome location and CXXC1 gene details page in the UCSC Genome Browser.
  • Human SPP1 genome location and SPP1 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q9P0U4 (CXXC-type zinc finger protein 1) at the PDBe-KB.

Further reading

  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein". J. Biol. Chem. 276 (48): 44669–44676. doi:10.1074/jbc.M107179200. PMID 11572867.
  • Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development". Mol. Cell. Biol. 21 (22): 7601–7606. doi:10.1128/MCB.21.22.7601-7606.2001. PMC 99931. PMID 11604496.
  • Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals". J. Biol. Chem. 277 (44): 42259–42267. doi:10.1074/jbc.M205054200. PMID 12200428.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex". J. Biol. Chem. 280 (50): 41725–41731. doi:10.1074/jbc.M508312200. PMID 16253997.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol. 26 (2): 80–90. doi:10.1089/dna.2006.0535. PMID 17328666.


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