Cell-cycle nonspecific antineoplastic agents
Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle.[1]
Alkylating antineoplastic agent and anthracyclins are two examples.
References
- ^ "Chemotherapy: The Basics". OncoLink. Archived from the original on 2007-03-14. Retrieved 2008-12-17.
Further reading
- Alberts DS, Golde DW (November 1974). "DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy". Cancer Res. 34 (11): 2911–4. PMID 4424360.
- Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M (1988). "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer Chemother. Pharmacol. 21 (3): 185–90. doi:10.1007/bf00262767. PMID 3129204.
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Intracellular chemotherapeutic agents / antineoplastic agents (L01)
(M phase)
Block microtubule assembly |
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Block microtubule disassembly |
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inhibitor
DNA precursors/ antimetabolites (S phase) |
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Topoisomerase inhibitors (S phase) |
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Crosslinking of DNA (CCNS) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III