Centrosomal protein 131

Protein-coding gene in the species Homo sapiens
CEP131
Identifiers
AliasesCEP131, AZ1, AZI1, ZA1, centrosomal protein 131
External IDsOMIM: 613479; MGI: 107440; HomoloGene: 7638; GeneCards: CEP131; OMA:CEP131 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CEP131
Genomic location for CEP131
Band17q25.3Start81,189,593 bp[1]
End81,222,999 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CEP131
Genomic location for CEP131
Band11|11 E2Start120,064,430 bp[2]
End120,086,827 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • gonad

  • tendon of biceps brachii

  • apex of heart

  • right testis

  • left testis

  • ventricular zone

  • ganglionic eminence

  • right hemisphere of cerebellum

  • anterior pituitary
Top expressed in
  • ventricular zone

  • Rostral migratory stream

  • seminiferous tubule

  • motor neuron

  • granulocyte

  • neural layer of retina

  • tail of embryo

  • medullary collecting duct

  • ganglionic eminence

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • protein binding
  • protein-containing complex binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • cell projection
  • intracellular membrane-bounded organelle
  • microtubule cytoskeleton
  • centriolar satellite
  • microtubule organizing center
  • acrosomal vesicle
  • intercellular bridge
  • cytoskeleton
  • cytoplasmic vesicle
  • ciliary transition zone
  • ciliary basal body
  • cilium
Biological process
  • positive regulation of intracellular protein transport
  • cell differentiation
  • regulation of centrosome duplication
  • multicellular organism development
  • intraciliary transport involved in cilium assembly
  • cell projection organization
  • G2/M transition of mitotic cell cycle
  • spermatogenesis
  • positive regulation of cell population proliferation
  • protein localization to centrosome
  • cell cycle
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
  • cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22994

12009

Ensembl

ENSG00000141577

ENSMUSG00000039781

UniProt

Q9UPN4

Q62036

RefSeq (mRNA)

NM_001009811
NM_014984
NM_001319228
NM_001319229

NM_009734

RefSeq (protein)

NP_001009811
NP_001306157
NP_001306158
NP_055799

NP_033864
NP_001390635
NP_001390663

Location (UCSC)Chr 17: 81.19 – 81.22 MbChr 11: 120.06 – 120.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein 131 also known as 5-azacytidine-induced protein 1 is a protein that in humans is encoded by the CEP131 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141577 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039781 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  6. ^ Aoto H, Miyake Y, Nakamura M, Tajima S (1997). "Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids". Genomics. 40 (1): 138–41. doi:10.1006/geno.1996.4546. PMID 9070930.
  7. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  8. ^ "Entrez Gene: AZI1 5-azacytidine induced 1".

Further reading

  • Aoto H, Tsuchida J, Nishina Y, Nishimune Y, Asano A, Tajima S (1995). "Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids". Eur. J. Biochem. 234 (1): 8–15. doi:10.1111/j.1432-1033.1995.008_c.x. PMID 8529672.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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