Choline transporter-like protein 1
Mammalian protein found in Homo sapiens
| SLC44A1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SLC44A1, CD92, CDW92, CHTL1, CTL1, solute carrier family 44 member 1, CONATOC | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606105; MGI: 2140592; HomoloGene: 11137; GeneCards: SLC44A1; OMA:SLC44A1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.[5][6][7]
Papillary glioneuronal tumors characteristically exhibit a gene fusion between SLC44A1 and PRKCA.[8][9][10] Loss of function mutations have been implicated in ethanolamine transport. [11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000070214 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028412 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stöckl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H (November 2001). "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells". Journal of Immunology. 167 (10): 5795–5804. doi:10.4049/jimmunol.167.10.5795. PMID 11698453.
- ^ O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (February 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
- ^ "Entrez Gene: SLC44A1 solute carrier family 44, member 1".
- ^ Bridge JA, Liu XQ, Sumegi J, Nelson M, Reyes C, Bruch LA, Rosenblum M, Puccioni MJ, Bowdiono BS, McComb RD (2013). "Identification of a Novel, Recurrent SLC44A1-PRKCA Fusion in Papillary Glioneuronal Tumor". Brain Pathology. 23 (2): 121–128. doi:10.1111/j.1750-3639.2012.00612.x. PMC 8029478. PMID 22725730.
- ^ Pages M, Lacroix L, Tauziede-Espariat A, Castel D, Daudigeos-Dubus E, Ridola V, et al. (2015). "Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion". Acta Neuropathologica Communications. 3: 85. doi:10.1186/s40478-015-0264-5. PMC 4681033. PMID 26671581. 85.
- ^ Nagaishi M, Nobusawa S, Matsumura N, Kono F, Ishiuchi S, Abe T, Ebato M, Wang Y, Hyodo A, Yokoo H, Nakazato Y (2016). "SLC44A1 – PRKCA fusion in papillary and rosette-forming glioneuronal tumors". Journal of Clinical Neuroscience. 23: 73–75. doi:10.1016/j.jocn.2015.04.021. PMID 26260115. S2CID 140207877.
- ^ Taylor A, Grapentine S, Ichhpuniani J, Bakovic M (2021). "Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters". J Biol Chem. 296: 100604. doi:10.1016/j.jbc.2021.100604. PMC 8081925. PMID 33789160.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
- Yuan Z, Tie A, Tarnopolsky M, Bakovic M (June 2006). "Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1" (PDF). Physiological Genomics. 26 (1): 76–90. doi:10.1152/physiolgenomics.00107.2005. PMID 16609143. S2CID 8181779. Archived from the original (PDF) on 2019-03-04.
- Fullerton MD, Wagner L, Yuan Z, Bakovic M (April 2006). "Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages" (PDF). American Journal of Physiology. Cell Physiology. 290 (4): C1230–C1238. doi:10.1152/ajpcell.00255.2005. PMID 16319125. S2CID 5096497. Archived from the original (PDF) on 2019-02-22.
- Li D, Wang F, Lai M, Chen Y, Zhang JF (February 2005). "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". The Journal of Neuroscience. 25 (8): 1914–23. doi:10.1523/JNEUROSCI.4790-04.2005. PMC 6726054. PMID 15728831.
- Traiffort E, Ruat M, O'Regan S, Meunier FM (March 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". Journal of Neurochemistry. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.
- Lecomte MJ, De Gois S, Guerci A, Ravassard P, Faucon Biguet N, Mallet J, Berrard S (February 2005). "Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia". Molecular and Cellular Neurosciences. 28 (2): 303–13. doi:10.1016/j.mcn.2004.09.014. PMID 15691711. S2CID 20828310.
- Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P (December 2003). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the National Academy of Sciences of the United States of America. 100 (26): 16006–11. Bibcode:2003PNAS..10016006F. doi:10.1073/pnas.2136600100. PMC 307683. PMID 14663150.
- Takekawa M, Maeda T, Saito H (August 1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". The EMBO Journal. 17 (16): 4744–52. doi:10.1093/emboj/17.16.4744. PMC 1170803. PMID 9707433.
External links
- SLC44A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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