ERAF

Protein-coding gene in the species Homo sapiens

AHSP

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
1W09, 1W0A, 1W0B, 1XZY, 1Y01, 1Z8U, 3IA3, 3OVU

Identifiers

Aliases

AHSP, EDRF, ERAF, alpha hemoglobin stabilizing protein

External IDs

OMIM: 605821; HomoloGene: 9605; GeneCards: AHSP; OMA:AHSP - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p11.2	Start	31,527,900 bp^[1]
Band	16p11.2	End	31,528,803 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trabecular bone

bone marrow cells

monocyte

blood

testicle

spleen

placenta

embryo

ganglionic eminence

right testis

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	unfolded protein binding hemoglobin binding protein binding
Cellular component	cytoplasm hemoglobin complex
Biological process	protein stabilization protein folding erythrocyte differentiation hemoglobin metabolic process hemopoiesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51327


n/a

Ensembl


ENSG00000169877


n/a

UniProt


Q9NZD4


n/a

RefSeq (mRNA)


NM_016633 NM_001318221 NM_001318222


n/a

RefSeq (protein)


NP_001305150 NP_001305151 NP_057717


n/a

Location (UCSC)

Chr 16: 31.53 – 31.53 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169877 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med. 7 (3): 361–4. doi:10.1038/85515. PMID 11231637. S2CID 11499070.
^ Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature. 417 (6890): 758–63. Bibcode:2002Natur.417..758K. doi:10.1038/nature00803. PMID 12066189. S2CID 4362675.
^ "Entrez Gene: ERAF erythroid associated factor".

Florio P, Rossi M, Sigurdardottir M, et al. (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A". Steroids. 68 (10–13): 801–7. doi:10.1016/S0039-128X(03)00137-5. PMID 14667971. S2CID 20953018.
Weiss MJ, Zhou S, Feng L, et al. (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci. 1054: 103–17. doi:10.1196/annals.1345.013. PMID 16339656. S2CID 23597786.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Gell D, Kong Y, Eaton SA, et al. (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein". J. Biol. Chem. 277 (43): 40602–9. doi:10.1074/jbc.M206084200. PMID 12192002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Viprakasit V, Tanphaichitr VS, Chinchang W, et al. (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia". Blood. 103 (9): 3296–9. doi:10.1182/blood-2003-11-3957. PMID 14715623.
Baudin-Creuza V, Vasseur-Godbillon C, Pato C, et al. (2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state". J. Biol. Chem. 279 (35): 36530–3. doi:10.1074/jbc.M405389200. PMID 15220346.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gallagher PG, Liem RI, Wong E, et al. (2006). "GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene". J. Biol. Chem. 280 (47): 39016–23. doi:10.1074/jbc.M506062200. PMID 16186125.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V, et al. (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone". J. Biol. Chem. 282 (9): 6398–404. doi:10.1074/jbc.M610543200. PMID 17194704.

PDB gallery

1w09: SOLUTION STRUCTURE OF THE CIS FORM OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP)
1w0a: SOLUTION STRUCTURE OF THE TRANS FORM OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP)
1w0b: SOLUTION STRUCTURE OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP) P30A MUTANT
1xzy: Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)
1y01: Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin
1z8u: Crystal structure of oxidized alpha hemoglobin bound to AHSP