ETM1

DRD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3PBL

Identifiers
AliasesDRD3, D3DR, ETM1, FET1, dopamine receptor D3
External IDsOMIM: 126451; MGI: 94925; HomoloGene: 623; GeneCards: DRD3; OMA:DRD3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for DRD3
Genomic location for DRD3
Band3q13.31Start114,127,580 bp[1]
End114,199,407 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for DRD3
Genomic location for DRD3
Band16 B4|16 28.44 cMStart43,574,389 bp[2]
End43,643,295 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • nucleus accumbens

  • putamen

  • caudate nucleus

  • granulocyte

  • prefrontal cortex

  • lymph node

  • hypothalamus

  • left testis

  • right testis
Top expressed in
  • morula

  • zygote

  • superior frontal gyrus

  • right ventricle

  • lumbar subsegment of spinal cord

  • ventricular zone

  • meninges

  • dentate gyrus of hippocampal formation granule cell

  • blastocyst

  • tibiofemoral joint
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signal transducer activity
  • G protein-coupled receptor activity
  • dopamine neurotransmitter receptor activity
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go
  • dopamine binding
  • protein domain specific binding
  • D1 dopamine receptor binding
  • adrenergic receptor activity
Cellular component
  • endocytic vesicle
  • apical part of cell
  • cell projection
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • dopaminergic synapse
  • glutamatergic synapse
  • GABA-ergic synapse
  • integral component of postsynaptic density membrane
Biological process
  • negative regulation of sodium:proton antiporter activity
  • dopamine receptor signaling pathway
  • dopamine metabolic process
  • regulation of circadian sleep/wake cycle, sleep
  • negative regulation of dopamine receptor signaling pathway
  • positive regulation of cell population proliferation
  • regulation of dopamine uptake involved in synaptic transmission
  • response to histamine
  • response to ethanol
  • prepulse inhibition
  • social behavior
  • learning
  • positive regulation of renal sodium excretion
  • arachidonic acid secretion
  • negative regulation of protein secretion
  • negative regulation of transcription by RNA polymerase II
  • gastric emptying
  • regulation of blood volume by renin-angiotensin
  • regulation of locomotion involved in locomotory behavior
  • cellular calcium ion homeostasis
  • regulation of locomotion
  • learning or memory
  • response to amphetamine
  • positive regulation of transcription by RNA polymerase II
  • positive regulation of cytokinesis
  • signal transduction
  • regulation of lipid metabolic process
  • regulation of multicellular organism growth
  • visual learning
  • G protein-coupled receptor internalization
  • regulation of dopamine secretion
  • negative regulation of protein kinase B signaling
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • locomotory behavior
  • behavioral response to cocaine
  • negative regulation of blood pressure
  • acid secretion
  • musculoskeletal movement, spinal reflex action
  • positive regulation of dopamine receptor signaling pathway
  • circadian regulation of gene expression
  • response to morphine
  • negative regulation of oligodendrocyte differentiation
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway
  • positive regulation of mitotic nuclear division
  • response to cocaine
  • synaptic transmission, dopaminergic
  • G protein-coupled receptor signaling pathway
  • autophagy
  • negative regulation of apoptotic process
  • regulation of neurotransmitter uptake
  • regulation of postsynaptic neurotransmitter receptor internalization
  • adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  • adenylate cyclase-activating adrenergic receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1814

13490

Ensembl

ENSG00000151577

ENSMUSG00000022705

UniProt

P35462

P30728

RefSeq (mRNA)
NM_000796
NM_001282563
NM_001290809
NM_033658
NM_033659

NM_033660
NM_033663

NM_007877

RefSeq (protein)

NP_000787
NP_001269492
NP_001277738
NP_387512

NP_031903

Location (UCSC)Chr 3: 114.13 – 114.2 MbChr 16: 43.57 – 43.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
essential tremor 1
Identifiers
SymbolETM1
HGNC3486
OMIM190300
Other data
LocusChr. 3 q13

ETM1 is a gene associated with essential tremor.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151577 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022705 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gulcher JR, Jónsson P, Kong A, et al. (1997). "Mapping of a familial essential tremor gene, FET1, to chromosome 3q13". Nat. Genet. 17 (1): 84–7. doi:10.1038/ng0997-84. PMID 9288103. S2CID 1506516.


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