DRD3 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | DRD3, D3DR, ETM1, FET1, dopamine receptor D3 |
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External IDs | OMIM: 126451; MGI: 94925; HomoloGene: 623; GeneCards: DRD3; OMA:DRD3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3q13.31 | Start | 114,127,580 bp[1] |
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End | 114,199,407 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16 B4|16 28.44 cM | Start | 43,574,389 bp[2] |
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End | 43,643,295 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- nucleus accumbens
- putamen
- caudate nucleus
- granulocyte
- prefrontal cortex
- lymph node
- hypothalamus
- left testis
- right testis
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| Top expressed in | - morula
- zygote
- superior frontal gyrus
- right ventricle
- lumbar subsegment of spinal cord
- ventricular zone
- meninges
- dentate gyrus of hippocampal formation granule cell
- blastocyst
- tibiofemoral joint
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- signal transducer activity
- G protein-coupled receptor activity
- dopamine neurotransmitter receptor activity
- dopamine neurotransmitter receptor activity, coupled via Gi/Go
- dopamine binding
- protein domain specific binding
- D1 dopamine receptor binding
- adrenergic receptor activity
| Cellular component | - endocytic vesicle
- apical part of cell
- cell projection
- integral component of membrane
- membrane
- plasma membrane
- integral component of plasma membrane
- dopaminergic synapse
- glutamatergic synapse
- GABA-ergic synapse
- integral component of postsynaptic density membrane
| Biological process | - negative regulation of sodium:proton antiporter activity
- dopamine receptor signaling pathway
- dopamine metabolic process
- regulation of circadian sleep/wake cycle, sleep
- negative regulation of dopamine receptor signaling pathway
- positive regulation of cell population proliferation
- regulation of dopamine uptake involved in synaptic transmission
- response to histamine
- response to ethanol
- prepulse inhibition
- social behavior
- learning
- positive regulation of renal sodium excretion
- arachidonic acid secretion
- negative regulation of protein secretion
- negative regulation of transcription by RNA polymerase II
- gastric emptying
- regulation of blood volume by renin-angiotensin
- regulation of locomotion involved in locomotory behavior
- cellular calcium ion homeostasis
- regulation of locomotion
- learning or memory
- response to amphetamine
- positive regulation of transcription by RNA polymerase II
- positive regulation of cytokinesis
- signal transduction
- regulation of lipid metabolic process
- regulation of multicellular organism growth
- visual learning
- G protein-coupled receptor internalization
- regulation of dopamine secretion
- negative regulation of protein kinase B signaling
- adenylate cyclase-activating dopamine receptor signaling pathway
- locomotory behavior
- behavioral response to cocaine
- negative regulation of blood pressure
- acid secretion
- musculoskeletal movement, spinal reflex action
- positive regulation of dopamine receptor signaling pathway
- circadian regulation of gene expression
- response to morphine
- negative regulation of oligodendrocyte differentiation
- adenylate cyclase-inhibiting dopamine receptor signaling pathway
- positive regulation of mitotic nuclear division
- response to cocaine
- synaptic transmission, dopaminergic
- G protein-coupled receptor signaling pathway
- autophagy
- negative regulation of apoptotic process
- regulation of neurotransmitter uptake
- regulation of postsynaptic neurotransmitter receptor internalization
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- adenylate cyclase-activating adrenergic receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_000796 NM_001282563 NM_001290809 NM_033658 NM_033659
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NM_033660 NM_033663 |
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RefSeq (protein) | |
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NP_000787 NP_001269492 NP_001277738 NP_387512 |
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Location (UCSC) | Chr 3: 114.13 – 114.2 Mb | Chr 16: 43.57 – 43.64 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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