EXOC7

Protein-coding gene in the species Homo sapiens
EXOC7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2PFT

Identifiers
AliasesEXOC7, 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, BLOM4, NEDSEBA
External IDsOMIM: 608163; MGI: 1859270; HomoloGene: 41019; GeneCards: EXOC7; OMA:EXOC7 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for EXOC7
Genomic location for EXOC7
Band17q25.1Start76,081,016 bp[1]
End76,121,576 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for EXOC7
Genomic location for EXOC7
Band11|11 E2Start116,178,827 bp[2]
End116,198,059 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • ganglionic eminence

  • parotid gland

  • ventricular zone

  • right lobe of thyroid gland

  • stromal cell of endometrium

  • external globus pallidus

  • pituitary gland

  • right hemisphere of cerebellum

  • left lobe of thyroid gland
Top expressed in
  • triceps brachii muscle

  • spermatocyte

  • spermatid

  • superior frontal gyrus

  • ventricular zone

  • muscle of thigh

  • primary visual cortex

  • temporal muscle

  • neural layer of retina

  • neural tube
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • cytosol
  • plasma membrane
  • growth cone membrane
  • exocyst
  • centriolar satellite
  • membrane
  • microtubule organizing center
  • Flemming body
Biological process
  • protein transport
  • regulation of entry of bacterium into host cell
  • regulation of macroautophagy
  • exocytosis
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23265

53413

Ensembl

ENSG00000182473

ENSMUSG00000020792

UniProt

Q9UPT5

O35250

RefSeq (mRNA)
NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_001282313

NM_001282314
NM_015219
NM_001375974
NM_001375975
NM_001375976

NM_001162872
NM_016857
NM_001347636
NM_001362838
NM_001362839

NM_001378960
NM_001378961

RefSeq (protein)
NP_001013861
NP_001138769
NP_001138770
NP_001138771
NP_001269242

NP_001269243
NP_056034
NP_001362903
NP_001362904
NP_001362905

NP_001156344
NP_001334565
NP_058553
NP_001349767
NP_001349768

NP_001365889
NP_001365890

Location (UCSC)Chr 17: 76.08 – 76.12 MbChr 11: 116.18 – 116.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Exo70 exocyst complex subunit
crystal structure of the s. cerevisiae exocyst component exo70p
Identifiers
SymbolExo70
PfamPF03081
Pfam clanCL0295
InterProIPR004140
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene.[5][6] It was formerly known as Exo70.

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae, this and other exocyst proteins have been observed in several other eukaryotes, including humans.[7] In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast.[7] It interacts with the Rho3 GTPase.[8] This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud).[9] In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.[10]

Interactions

EXOC7 has been shown to interact with EXOC4[11][12] and RHOQ.[12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182473 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020792 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: EXOC7 exocyst complex component 7".
  7. ^ a b TerBush DR, Maurice T, Roth D, Novick P (December 1996). "The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae". EMBO J. 15 (23): 6483–94. doi:10.1002/j.1460-2075.1996.tb01039.x. PMC 452473. PMID 8978675.
  8. ^ Robinson NG, Guo L, Imai J, Toh-E A, Matsui Y, Tamanoi F (May 1999). "Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70". Mol. Cell. Biol. 19 (5): 3580–7. doi:10.1128/MCB.19.5.3580. PMC 84150. PMID 10207081.
  9. ^ Adamo JE, Rossi G, Brennwald P (December 1999). "The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity". Mol. Biol. Cell. 10 (12): 4121–33. doi:10.1091/mbc.10.12.4121. PMC 25747. PMID 10588647.
  10. ^ Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (December 1997). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. Bibcode:1997PNAS...9414438K. doi:10.1073/pnas.94.26.14438. PMC 25013. PMID 9405631.
  11. ^ Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–530. doi:10.1038/ncb990. PMID 12738960. S2CID 13444388.
  12. ^ a b Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–633. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl:2027.42/62982. PMID 12687004. S2CID 4395760.

Further reading

  • Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–14443. Bibcode:1997PNAS...9414438K. doi:10.1073/pnas.94.26.14438. PMC 25013. PMID 9405631.
  • Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Soudeyns H, Champagne P, Holloway CL, Silvestri GU, Ringuette N, Samson J, Lapointe N, Sékaly RP (2000). "Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping". J. Infect. Dis. 181 (1): 107–120. doi:10.1086/315181. PMID 10608757.
  • Ignatovich O, Tomlinson IM, Popov AV, Brüggemann M, Winter G (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–465. doi:10.1006/jmbi.1999.3243. PMID 10610771.
  • Holtmeier W, Hennemann A, Caspary WF (2000). "IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated". Gastroenterology. 119 (5): 1253–1266. doi:10.1053/gast.2000.20219. PMID 11054383.
  • Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–29797. doi:10.1074/jbc.C100320200. PMID 11406615.
  • Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–633. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl:2027.42/62982. PMID 12687004. S2CID 4395760.
  • Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–51748. doi:10.1074/jbc.M308702200. PMID 14525976.
  • Wang S, Liu Y, Adamson CL, Valdez G, Guo W, Hsu SC (2005). "The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization". J. Biol. Chem. 279 (34): 35958–35966. doi:10.1074/jbc.M313778200. PMID 15205466.
  • Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2784–2789. Bibcode:2005PNAS..102.2784X. doi:10.1073/pnas.0409871102. PMC 549493. PMID 15705715.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • v
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  • 2pft: The Crystal Structure of Mouse Exo70 Reveals Unique Features of the Mammalian Exocyst
    2pft: The Crystal Structure of Mouse Exo70 Reveals Unique Features of the Mammalian Exocyst
This article incorporates text from the public domain Pfam and InterPro: IPR004140


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