FCHO1

Protein-coding gene in the species Homo sapiens

FCHO1
Identifiers
AliasesFCHO1, FCH domain only 1, FCH and mu domain containing endocytic adaptor 1
External IDsOMIM: 613437; MGI: 1921265; HomoloGene: 22869; GeneCards: FCHO1; OMA:FCHO1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FCHO1
Genomic location for FCHO1
Band19p13.11Start17,747,718 bp[1]
End17,788,568 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for FCHO1
Genomic location for FCHO1
Band8|8 B3.3Start72,161,031 bp[2]
End72,178,360 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • C1 segment

  • oocyte

  • right frontal lobe

  • blood

  • right hemisphere of cerebellum

  • lymph node

  • monocyte

  • putamen

  • prefrontal cortex
Top expressed in
  • superior frontal gyrus

  • primary visual cortex

  • thymus

  • perirhinal cortex

  • entorhinal cortex

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • lumbar subsegment of spinal cord

  • primary motor cortex

  • olfactory tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • AP-2 adaptor complex binding
  • protein binding
  • phospholipid binding
  • microtubule binding
  • cytoskeletal protein binding
  • tubulin binding
Cellular component
  • plasma membrane
  • clathrin-coated pit
  • membrane
  • clathrin-coated vesicle
  • nucleoplasm
  • cytosol
  • cytoplasm
  • cytoskeleton
  • AP-2 adaptor complex
Biological process
  • clathrin-dependent endocytosis
  • endocytosis
  • clathrin coat assembly
  • membrane organization
  • plasma membrane tubulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23149

74015

Ensembl

ENSG00000130475

ENSMUSG00000070000

UniProt

O14526

Q8K285

RefSeq (mRNA)

NM_001161357
NM_001161358
NM_001161359
NM_015122

NM_028715

RefSeq (protein)

NP_001154829
NP_001154830
NP_001154831
NP_055937

NP_082991

Location (UCSC)Chr 19: 17.75 – 17.79 MbChr 8: 72.16 – 72.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130475 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070000 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FCH domain only 1". Retrieved 2017-05-13.

Further reading

  • Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K (2007). "Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8. doi:10.1271/bbb.60720. PMID 17617719. S2CID 21432830.
  • Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010). "FCHo proteins are nucleators of clathrin-mediated endocytosis". Science. 328 (5983): 1281–4. Bibcode:2010Sci...328.1281H. doi:10.1126/science.1188462. PMC 2883440. PMID 20448150.
  • Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM (2012). "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning". Nat. Cell Biol. 14 (5): 488–501. doi:10.1038/ncb2473. PMC 3354769. PMID 22484487.


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