FMNL1

Protein-coding gene in the species Homo sapiens
FMNL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4YDH

Identifiers
AliasesFMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDsOMIM: 604656; MGI: 1888994; HomoloGene: 136798; GeneCards: FMNL1; OMA:FMNL1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for FMNL1
Genomic location for FMNL1
Band17q21.31Start45,221,444 bp[1]
End45,247,319 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for FMNL1
Genomic location for FMNL1
Band11|11 E1Start103,061,933 bp[2]
End103,089,727 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • blood

  • spleen

  • right lung

  • upper lobe of left lung

  • lymph node

  • bone marrow cells

  • appendix

  • gallbladder
Top expressed in
  • granulocyte

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • perirhinal cortex

  • tibiofemoral joint

  • thymus

  • entorhinal cortex

  • lumbar spinal ganglion

  • interventricular septum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • profilin binding
  • GTPase activating protein binding
  • actin filament binding
  • protein binding
  • actin binding
  • molecular function
Cellular component
  • cytoplasm
  • cell projection
  • membrane
  • plasma membrane
  • cell cortex
  • phagocytic vesicle
  • bleb
  • extracellular exosome
  • cytoplasmic vesicle
  • cytosol
  • integral component of membrane
Biological process
  • actin filament severing
  • substrate-dependent cell migration
  • cytoskeleton organization
  • regulation of cell shape
  • cellular component organization
  • cortical actin cytoskeleton organization
  • actin cytoskeleton organization
  • cellular process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

752

57778

Ensembl

ENSG00000184922

ENSMUSG00000055805

UniProt

O95466

Q9JL26

RefSeq (mRNA)

NM_005892

NM_001077698
NM_019679

RefSeq (protein)

NP_005883

NP_001071166
NP_062653
NP_001390541
NP_001390542
NP_001390543

NP_001390544
NP_001390545
NP_001390546
NP_001390547

Location (UCSC)Chr 17: 45.22 – 45.25 MbChr 11: 103.06 – 103.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.[5][6]

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.[6]

Interactions

FMNL1 has been shown to interact with Profilin 1,[7] PFN2[7] and RAC1.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184922 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055805 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ (November 1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum Genet. 103 (3): 340–345. doi:10.1007/s004390050827. PMID 9799091. S2CID 11305597.
  6. ^ a b "Entrez Gene: FMNL1 formin-like 1".
  7. ^ a b c Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18). UNITED STATES: 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683.

Further reading

  • Kennerson ML, Nassif NT, Nicholson GA (1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–112. doi:10.1006/geno.1998.5453. PMID 9787083.
  • Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18): 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. PMC 86228. PMID 10958683.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Katoh M, Katoh M (2003). "Identification and characterization of human DAAM2 gene in silico". Int. J. Oncol. 22 (4): 915–20. doi:10.3892/ijo.22.4.915. PMID 12632087.
  • Katoh M, Katoh M (2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
  • Favaro PM, de Souza Medina S, Traina F, et al. (2004). "Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt". Biochem. Biophys. Res. Commun. 311 (2): 365–371. doi:10.1016/j.bbrc.2003.10.012. PMID 14592423.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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