FSTL3

Protein-coding gene in the species Homo sapiens

FSTL3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2KCX, 3B4V, 3SEK

Identifiers

Aliases

FSTL3, FLRG, FSRP, follistatin like 3

External IDs

OMIM: 605343; MGI: 1890391; HomoloGene: 4280; GeneCards: FSTL3; OMA:FSTL3 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	676,392 bp^[1]
Band	19p13.3	End	683,392 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 C1	Start	79,613,106 bp^[2]
Band	10\|10 C1	End	79,618,464 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

tibial nerve

ascending aorta

left coronary artery

apex of heart

left adrenal cortex

left uterine tube

upper lobe of left lung

gastric mucosa

right adrenal gland

Top expressed in

ascending aorta

aortic valve

tunica media of zone of aorta

belly cord

morula

decidua

efferent ductule

right lung lobe

stroma of bone marrow

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	fibronectin binding activin binding protein binding
Cellular component	Golgi apparatus secretory granule nucleoplasm extracellular region neuron projection terminus nucleus extracellular space endoplasmic reticulum lumen
Biological process	male gonad development regulation of transcription, DNA-templated negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossification negative regulation of osteoclast differentiation positive regulation of cell-cell adhesion kidney development lung development regulation of transcription by RNA polymerase II adrenal gland development transcription, DNA-templated negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway cellular response to metal ion hematopoietic progenitor cell differentiation spermatogenesis positive regulation of transcription by RNA polymerase II post-translational protein modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10272


83554

Ensembl


ENSG00000070404


ENSMUSG00000020325

UniProt


O95633


Q9EQC7

RefSeq (mRNA)


NM_005860


NM_031380

RefSeq (protein)


NP_005851


NP_113557

Location (UCSC)

Chr 19: 0.68 – 0.68 Mb

Chr 10: 79.61 – 79.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.^[5]^[6]^[7]

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070404 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020325 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (Aug 1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders". Oncogene. 16 (22): 2949–54. doi:10.1038/sj.onc.1201807. PMID 9671416. S2CID 10736135.
^ Glusman G, Kaur A, Hood L, Rowen L (Nov 2004). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution". BMC Evol Biol. 4: 43. doi:10.1186/1471-2148-4-43. PMC 533870. PMID 15527507.
^ ^a ^b "Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)".

Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis". Mol. Cell. Endocrinol. 225 (1–2): 109–18. doi:10.1016/j.mce.2004.07.009. PMID 15451575. S2CID 25430198.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Tortoriello DV, Sidis Y, Holtzman DA, et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–34. doi:10.1210/endo.142.8.8319. PMID 11459787.
Bartholin L, Maguer-Satta V, Hayette S, et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene. 20 (39): 5409–19. doi:10.1038/sj.onc.1204720. PMID 11571638. S2CID 29503172.
Bartholin L, Maguer-Satta V, Hayette S, et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene. 21 (14): 2227–35. doi:10.1038/sj.onc.1205294. PMID 11948405. S2CID 1065429.
Hill JJ, Davies MV, Pearson AA, et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum". J. Biol. Chem. 277 (43): 40735–41. doi:10.1074/jbc.M206379200. PMID 12194980.
Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod. 8 (11): 992–7. doi:10.1093/molehr/8.11.992. PMID 12397211.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Maguer-Satta V, Bartholin L, Jeanpierre S, et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2): 110–20. doi:10.1016/S0014-4827(02)00013-7. PMID 12531697.
Wang HQ, Takebayashi K, Tsuchida K, et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. doi:10.1210/jc.2002-021758. PMID 12970321.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice". Mol. Endocrinol. 18 (4): 979–94. doi:10.1210/me.2003-0364. PMID 14739256.
Florio P, Ciarmela P, Toti P, et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol. 218 (1–2): 129–35. doi:10.1016/j.mce.2003.12.019. PMID 15130517. S2CID 42635058.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Saito S, Sidis Y, Mukherjee A, et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3". Endocrinology. 146 (12): 5052–62. doi:10.1210/en.2005-0833. PMID 16150905.
Okamoto A, Endo H, Kalionis B, et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta. 27 (2–3): 317–21. doi:10.1016/j.placenta.2004.12.007. PMID 16338475.