Frizzled-6

Protein-coding gene in the species Homo sapiens
FZD6
Identifiers
AliasesFZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDsOMIM: 603409; MGI: 108474; HomoloGene: 2617; GeneCards: FZD6; OMA:FZD6 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for FZD6
Genomic location for FZD6
Band8q22.3Start103,298,433 bp[1]
End103,332,866 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for FZD6
Genomic location for FZD6
Band15 B3.1|15 15.22 cMStart38,869,429 bp[2]
End38,901,583 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • caput epididymis

  • Epithelium of choroid plexus

  • skin of thigh

  • skin of hip

  • corpus epididymis

  • epithelium of nasopharynx

  • palpebral conjunctiva

  • secondary oocyte

  • hair follicle
Top expressed in
  • lip

  • uterus

  • genital tubercle

  • lens

  • esophagus

  • zone of skin

  • heart

  • spermatocyte

  • urethra

  • lower respiratory tract
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • protein binding
  • Wnt-activated receptor activity
  • ubiquitin protein ligase binding
  • transmembrane signaling receptor activity
  • G protein-coupled receptor activity
  • Wnt-protein binding
  • amyloid-beta binding
Cellular component
  • membrane
  • apical part of cell
  • integral component of plasma membrane
  • cell surface
  • apicolateral plasma membrane
  • apical plasma membrane
  • cytoplasmic vesicle membrane
  • cytoplasmic vesicle
  • plasma membrane
  • integral component of membrane
Biological process
  • hair follicle development
  • G protein-coupled receptor signaling pathway
  • non-canonical Wnt signaling pathway
  • establishment of planar polarity
  • cell proliferation in midbrain
  • Wnt signaling pathway
  • negative regulation of DNA-binding transcription factor activity
  • platelet activation
  • multicellular organism development
  • Wnt signaling pathway, planar cell polarity pathway
  • embryonic nail plate morphogenesis
  • cell surface receptor signaling pathway
  • neural tube closure
  • inner ear morphogenesis
  • midbrain morphogenesis
  • negative regulation of canonical Wnt signaling pathway
  • signal transduction
  • midbrain development
  • Wnt signaling pathway, calcium modulating pathway
  • establishment of body hair planar orientation
  • canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8323

14368

Ensembl

ENSG00000164930

ENSMUSG00000022297

UniProt

O60353

Q61089

RefSeq (mRNA)

NM_001164615
NM_001164616
NM_003506
NM_001317796

NM_001162494
NM_008056

RefSeq (protein)
NP_001158087
NP_001158088
NP_001304725
NP_003497
NP_001158087.1

NP_003497.2

NP_001155966
NP_032082

Location (UCSC)Chr 8: 103.3 – 103.33 MbChr 15: 38.87 – 38.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.[5][6][7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[7] Fz-6 is believed to be the receptor for the WNT4 ligand.[8]

Interactions

Fz-6 has been shown to interact with secreted frizzled-related protein 1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164930 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022297 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.
  6. ^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.
  7. ^ a b "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".
  8. ^ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.
  9. ^ Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.

Further reading

  • Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Feb 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". The Journal of Biological Chemistry. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
  • Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
  • Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.
  • Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Sirchia R, Luparello C (May 2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biological Chemistry. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. S2CID 2286919.
  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-01-24. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Class F: Frizzled & Smoothened
Frizzled
Smoothened