GGA3

Protein-coding gene in the species Homo sapiens
GGA3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8

Identifiers
AliasesGGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
External IDsOMIM: 606006; MGI: 2384159; HomoloGene: 121703; GeneCards: GGA3; OMA:GGA3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GGA3
Genomic location for GGA3
Band17q25.1Start75,236,599 bp[1]
End75,262,363 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for GGA3
Genomic location for GGA3
Band11|11 E2Start115,475,081 bp[2]
End115,494,877 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • granulocyte

  • pylorus

  • gastric mucosa

  • spleen

  • monocyte

  • nipple

  • lymph node

  • upper lobe of left lung

  • fundus
Top expressed in
  • zygote

  • secondary oocyte

  • neural layer of retina

  • tail of embryo

  • primary visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • yolk sac

  • facial motor nucleus

  • genital tubercle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin binding
Cellular component
  • endosome
  • trans-Golgi network
  • endosome membrane
  • intracellular anatomical structure
  • membrane
  • clathrin adaptor complex
  • Golgi apparatus
  • early endosome membrane
  • recycling endosome membrane
  • early endosome
  • recycling endosome
Biological process
  • protein transport
  • intracellular protein transport
  • positive regulation of protein catabolic process
  • vesicle-mediated transport
  • protein localization to lysosome
  • regulation of protein stability
  • protein destabilization
  • endocytic recycling
  • protein localization to cell surface
  • Golgi to plasma membrane protein transport
  • negative regulation of amyloid-beta formation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23163

260302

Ensembl

ENSG00000125447

ENSMUSG00000020740

UniProt

Q9NZ52

Q8BMI3

RefSeq (mRNA)
NM_001172703
NM_001172704
NM_001291641
NM_001291642
NM_014001

NM_138619

NM_001252067
NM_173048

RefSeq (protein)
NP_001166174
NP_001166175
NP_001278570
NP_001278571
NP_054720

NP_619525

NP_001238996
NP_766636

Location (UCSC)Chr 17: 75.24 – 75.26 MbChr 11: 115.48 – 115.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.[5][6]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.[7]

Interactions

GGA3 has been shown to interact with ARF1[5][8] and ARF3.[6][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125447 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020740 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". The Journal of Cell Biology. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
  6. ^ a b Boman AL, Zhang C, Zhu X, Kahn RA (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
  7. ^ "Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3".
  8. ^ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
  9. ^ Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.

Further reading

  • Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  • Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (April 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  • Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  • Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
  • Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (June 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
  • Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH (February 2002). "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature. 415 (6874): 933–7. Bibcode:2002Natur.415..933M. doi:10.1038/415933a. PMID 11859375. S2CID 4430757.
  • Takatsu H, Yoshino K, Toda K, Nakayama K (July 2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". The Biochemical Journal. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
  • Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS (July 2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology. 9 (7): 532–6. doi:10.1038/nsb807. PMID 12032548. S2CID 23740463.
  • Doray B, Bruns K, Ghosh P, Kornfeld SA (June 2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
  • Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
  • Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (September 2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science. 297 (5587): 1700–3. Bibcode:2002Sci...297.1700D. doi:10.1126/science.1075327. PMID 12215646. S2CID 8810528.
  • Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
  • Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  • Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y (July 2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications. 306 (3): 687–92. doi:10.1016/S0006-291X(03)01032-5. PMID 12810073.
  • He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (October 2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry. 42 (42): 12174–80. doi:10.1021/bi035199h. PMID 14567678.
  • Ghosh P, Griffith J, Geuze HJ, Kornfeld S (November 2003). "Mammalian GGAs act together to sort mannose 6-phosphate receptors". The Journal of Cell Biology. 163 (4): 755–66. doi:10.1083/jcb.200308038. PMC 2173681. PMID 14638859.
  • Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K (February 2004). "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". The Journal of Biological Chemistry. 279 (8): 7105–11. doi:10.1074/jbc.M311702200. PMID 14660606.
  • v
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  • e
  • 1jpl: GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor
    1jpl: GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor
  • 1juq: GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose 6-phosphate receptor
    1juq: GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose 6-phosphate receptor
  • 1lf8: Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
    1lf8: Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
  • 1p4u: CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE
    1p4u: CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE
  • 1wr6: Crystal structure of GGA3 GAT domain in complex with ubiquitin
    1wr6: Crystal structure of GGA3 GAT domain in complex with ubiquitin
  • 1yd8: COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN
    1yd8: COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN
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