GINS2

Protein-coding gene in the species Homo sapiens
GINS2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E9X, 2EHO, 2Q9Q

Identifiers
AliasesGINS2, HSPC037, PSF2, Pfs2, GINS complex subunit 2
External IDsOMIM: 610609; MGI: 1921019; HomoloGene: 41105; GeneCards: GINS2; OMA:GINS2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for GINS2
Genomic location for GINS2
Band16q24.1Start85,676,198 bp[1]
End85,690,073 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for GINS2
Genomic location for GINS2
Band8|8 E1Start121,305,372 bp[2]
End121,316,043 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • ventricular zone

  • embryo

  • ganglionic eminence

  • sperm

  • bone marrow

  • mucosa of transverse colon

  • trabecular bone

  • testicle
Top expressed in
  • yolk sac

  • tail of embryo

  • embryo

  • embryo

  • genital tubercle

  • epiblast

  • blastocyst

  • ventricular zone

  • zygote

  • primary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • 3'-5' DNA helicase activity
  • protein binding
Cellular component
  • GINS complex
  • replication fork protection complex
  • nucleus
  • nucleoplasm
Biological process
  • DNA replication
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via break-induced replication
  • mitotic DNA replication initiation
  • DNA duplex unwinding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51659

272551

Ensembl

ENSG00000131153

ENSMUSG00000031821

UniProt

Q9Y248

Q9D600

RefSeq (mRNA)

NM_016095

NM_178856

RefSeq (protein)

NP_057179

NP_849187

Location (UCSC)Chr 16: 85.68 – 85.69 MbChr 8: 121.31 – 121.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene.[5][6][7]

Interactions

GINS2 has been shown to interact with CHEK2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131153 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031821 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ^ "Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog)".
  8. ^ Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H (2003). "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast". Genes Dev. 17 (9): 1153–65. doi:10.1101/gad.1065903. PMC 196052. PMID 12730134.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.
  • v
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  • 2e9x: The crystal structure of human GINS core complex
    2e9x: The crystal structure of human GINS core complex


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