GPS1

Protein-coding gene in the species Homo sapiens

GPS1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4D10, 4D18, 4WSN

Identifiers

Aliases

GPS1, COPS1, CSN1, SGN1, G protein pathway suppressor 1

External IDs

OMIM: 601934; MGI: 2384801; HomoloGene: 3046; GeneCards: GPS1; OMA:GPS1 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.3	Start	82,050,691 bp^[1]
Band	17q25.3	End	82,057,470 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	120,675,098 bp^[2]
Band	11\|11 E2	End	120,679,928 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

muscle of thigh

right hemisphere of cerebellum

gastrocnemius muscle

right frontal lobe

anterior pituitary

right testis

left testis

ganglionic eminence

right lobe of liver

Top expressed in

spermatocyte

lens

mesencephalon

neural tube

rhombencephalon

adrenal gland

dentate gyrus of hippocampal formation granule cell

olfactory bulb

ventricular zone

striatum of neuraxis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GTPase inhibitor activity protein binding
Cellular component	cytoplasm COP9 signalosome nucleus nucleoplasm cytosol
Biological process	JNK cascade transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA damage recognition negative regulation of GTPase activity protein deneddylation post-translational protein modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2873


209318

Ensembl


ENSG00000169727


ENSMUSG00000025156

UniProt


Q13098


Q99LD4

RefSeq (mRNA)

NM_004127 NM_212492 NM_001321089 NM_001321090 NM_001321091
NM_001321092 NM_001321093 NM_001330539 NM_001330541


NM_001177874 NM_145370 NM_001346709 NM_001363440

RefSeq (protein)

NP_001308018 NP_001308019 NP_001308020 NP_001308021 NP_001308022
NP_001317468 NP_001317470 NP_004118 NP_997657


n/a

Location (UCSC)

Chr 17: 82.05 – 82.06 Mb

Chr 11: 120.68 – 120.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.^[5]^[6]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169727 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025156 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
^ ^a ^b "Entrez Gene: GPS1 G protein pathway suppressor 1".

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295. S2CID 37458780.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Spain BH, Bowdish KS, Pacal AR, et al. (1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Mol. Cell. Biol. 16 (12): 6698–706. doi:10.1128/mcb.16.12.6698. PMC 231672. PMID 8943324.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. S2CID 13873982.
Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626. S2CID 39308598.
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi:10.1074/jbc.M208709200. PMID 12324474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Serino G, Su H, Peng Z, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang Y, Lu C, Wei H, et al. (2004). "Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity". FEBS Lett. 572 (1–3): 85–91. doi:10.1016/j.febslet.2004.07.012. PMID 15304329. S2CID 23573449.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.