Gasdermin A

Protein-coding gene in the species Homo sapiens
GSDMA
Identifiers
AliasesGSDMA, GSDM, GSDM1, FKSG9, gasdermin A
External IDsOMIM: 611218; MGI: 1889509; HomoloGene: 10962; GeneCards: GSDMA; OMA:GSDMA - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GSDMA
Genomic location for GSDMA
Band17q21.1Start39,953,263 bp[1]
End39,977,768 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for GSDMA
Genomic location for GSDMA
Band11|11 DStart98,555,177 bp[2]
End98,568,534 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • skin of abdomen

  • granulocyte

  • placenta

  • gastric mucosa

  • gonad

  • smooth muscle tissue

  • appendix

  • gallbladder

  • duodenum
Top expressed in
  • esophagus

  • lip

  • skin of back

  • seminal vesicula

  • skin of external ear

  • hair follicle

  • skin of abdomen

  • epithelium of gastric gland

  • belly cord

  • seminiferous tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatidylserine binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • phosphatidylinositol-4-phosphate binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • cytosol
  • plasma membrane
  • membrane
Biological process
  • programmed cell death
  • apoptotic process
  • pyroptosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

284110

57911

Ensembl

ENSG00000167914

ENSMUSG00000017204

UniProt

Q96QA5

Q9EST1

RefSeq (mRNA)

NM_178171

NM_021347

RefSeq (protein)

NP_835465

NP_067322

Location (UCSC)Chr 17: 39.95 – 39.98 MbChr 11: 98.56 – 98.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gasdermin A is a protein that in humans is encoded by the GSDMA gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167914 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017204 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Gasdermin A". Retrieved 2016-08-26.

Further reading

  • Katoh M, Katoh M (2004). "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24.4.757. PMID 15010812.


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