HLF (gene)

Protein-coding gene in the species Homo sapiens

HLF
Identifiers
AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDsOMIM: 142385; MGI: 96108; HomoloGene: 31074; GeneCards: HLF; OMA:HLF - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HLF
Genomic location for HLF
Band17q22Start55,264,960 bp[1]
End55,325,187 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HLF
Genomic location for HLF
Band11 C|11 55.03 cMStart90,227,362 bp[2]
End90,281,721 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • orbitofrontal cortex

  • Brodmann area 46

  • superior frontal gyrus

  • prefrontal cortex

  • middle temporal gyrus

  • postcentral gyrus

  • lateral nuclear group of thalamus

  • Brodmann area 23

  • Brodmann area 9
Top expressed in
  • lateral geniculate nucleus

  • medial dorsal nucleus

  • inferior colliculus

  • medial geniculate nucleus

  • primary motor cortex

  • olfactory tubercle

  • mammillary body

  • pontine nuclei

  • median eminence

  • vestibular membrane of cochlear duct
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • double-stranded DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • multicellular organism development
  • skeletal muscle cell differentiation
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • rhythmic process
  • positive regulation of transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3131

217082

Ensembl

ENSG00000108924

ENSMUSG00000003949

UniProt

Q16534

Q8BW74

RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

NP_766151
NP_001390914
NP_001390915
NP_001390917
NP_001390918

NP_001390920
NP_001390922
NP_001390924
NP_001390926

Location (UCSC)Chr 17: 55.26 – 55.33 MbChr 11: 90.23 – 90.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108924 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003949 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. Bibcode:1992Sci...257..531I. doi:10.1126/science.1386162. PMID 1386162.
  6. ^ a b "Entrez Gene: HLF hepatic leukemia factor".

Further reading

  • LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human leukemia". Frontiers in Bioscience. 8: s206-22. doi:10.2741/1030. PMID 12700034.
  • Hunger SP, Ohyashiki K, Toyama K, Cleary ML (September 1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia". Genes & Development. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.
  • Falvey E, Fleury-Olela F, Schibler U (September 1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences". The EMBO Journal. 14 (17): 4307–17. doi:10.1002/j.1460-2075.1995.tb00105.x. PMC 394515. PMID 7556072.
  • Hunger SP, Brown R, Cleary ML (September 1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF". Molecular and Cellular Biology. 14 (9): 5986–96. doi:10.1128/mcb.14.9.5986. PMC 359124. PMID 8065331.
  • Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT (May 1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein". Molecular and Cellular Biology. 14 (5): 3403–13. doi:10.1128/mcb.14.5.3403. PMC 358705. PMID 8164688.
  • Hunger SP (February 1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis". Blood. 87 (4): 1211–24. doi:10.1182/blood.v87.4.1211.bloodjournal8741211. PMID 8608207.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML (June 1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood. 87 (11): 4607–17. doi:10.1182/blood.V87.11.4607.bloodjournal87114607. PMID 8639829.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y (July 1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock". Biochemical and Biophysical Research Communications. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.
  • Inukai T, Inaba T, Ikushima S, Look AT (October 1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF". Molecular and Cellular Biology. 18 (10): 6035–43. doi:10.1128/mcb.18.10.6035. PMC 109189. PMID 9742120.
  • Begbie M, Mueller C, Lillicrap D (February 1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes". DNA and Cell Biology. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.
  • Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y (April 1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300". The EMBO Journal. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMC 1171276. PMID 10202154.
  • Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H (May 1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia". Blood. 93 (9): 2780–90. doi:10.1182/blood.v93.9.2780.409a47_2780_2790. PMID 10216071.
  • Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H (April 2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein". Blood. 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701. S2CID 12473166.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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