HSPB6

Protein-coding gene in the species Homo sapiens

HSPB6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4JUS, 4JUT

Identifiers
AliasesHSPB6, HEL55, Hsp20, PPP1R91, heat shock protein family B (small) member 6
External IDsOMIM: 610695; MGI: 2685325; HomoloGene: 36931; GeneCards: HSPB6; OMA:HSPB6 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HSPB6
Genomic location for HSPB6
Band19q13.12Start35,754,566 bp[1]
End35,758,079 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for HSPB6
Genomic location for HSPB6
Band7|7 B1Start30,251,603 bp[2]
End30,254,868 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • apex of heart

  • gastrocnemius muscle

  • decidua

  • right coronary artery

  • left coronary artery

  • left uterine tube

  • canal of the cervix

  • popliteal artery

  • tibial arteries
Top expressed in
  • interventricular septum

  • extraocular muscle

  • temporal muscle

  • ankle

  • soleus muscle

  • vastus lateralis muscle

  • sternocleidomastoid muscle

  • muscle of thigh

  • triceps brachii muscle

  • digastric muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural constituent of eye lens
  • protein homodimerization activity
  • protein binding
  • unfolded protein binding
  • chaperone binding
Cellular component
  • nucleus
  • cytoplasm
  • extracellular region
Biological process
  • regulation of muscle contraction
  • negative regulation of cardiac muscle cell apoptotic process
  • positive regulation of angiogenesis
  • chaperone-mediated protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

126393

243912

Ensembl

ENSG00000004776

ENSMUSG00000036854

UniProt

O14558

Q5EBG6

RefSeq (mRNA)

NM_144617

NM_001012401
NM_001364179

RefSeq (protein)

NP_653218

NP_001012401
NP_001351108

Location (UCSC)Chr 19: 35.75 – 35.76 MbChr 7: 30.25 – 30.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene.[5][6][7]

HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin).[8]

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance[9] and in smooth and cardiac muscle.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004776 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036854 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress & Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 (inactive 2024-04-11). PMC 514853. PMID 12820654.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
  6. ^ Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID 14717697.
  7. ^ "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6".
  8. ^ Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. doi:10.1016/S0021-9258(17)36606-1. PMID 8195168.
  9. ^ Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress & Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC 2866971. PMID 19568960.
  10. ^ Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC 2581864. PMID 18579210.
  11. ^ Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID 16099377.

Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Fontaine JM, Sun X, Benndorf R, Welsh MJ (2005). "Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3". Biochem. Biophys. Res. Commun. 337 (3): 1006–11. doi:10.1016/j.bbrc.2005.09.148. PMID 16225851.
  • Flynn CR, Smoke CC, Furnish E, et al. (2007). "Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli". Protein Expr. Purif. 52 (1): 50–8. doi:10.1016/j.pep.2006.08.015. PMC 1839877. PMID 17084643.
  • Chernik IS, Seit-Nebi AS, Marston SB, Gusev NB (2007). "Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma". Mol. Cell. Biochem. 295 (1–2): 9–17. doi:10.1007/s11010-006-9266-8. PMID 17109079. S2CID 6389210.
  • Overview of all the structural information available in the PDB for UniProt: O14558 (Heat shock protein beta-6) at the PDBe-KB.


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