KCTD15

Protein-coding gene in the species Homo sapiens
KCTD15
Identifiers
AliasesKCTD15, potassium channel tetramerization domain containing 15
External IDsOMIM: 615240; MGI: 2385276; HomoloGene: 11450; GeneCards: KCTD15; OMA:KCTD15 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KCTD15
Genomic location for KCTD15
Band19q13.11Start33,795,933 bp[1]
End33,815,763 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for KCTD15
Genomic location for KCTD15
Band7|7 B1- B2Start34,338,439 bp[2]
End34,356,157 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • left uterine tube

  • skin of hip

  • skin of abdomen

  • right coronary artery

  • body of uterus

  • skin of leg

  • ectocervix

  • human penis
Top expressed in
  • otic vesicle

  • hand

  • lip

  • foot

  • triceps brachii muscle

  • vastus lateralis muscle

  • medial head of gastrocnemius muscle

  • sternocleidomastoid muscle

  • skeletal muscle tissue

  • temporal muscle
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

79047

233107

Ensembl

ENSG00000153885

ENSMUSG00000030499

UniProt

Q96SI1

Q8K0E1

RefSeq (mRNA)

NM_001129994
NM_001129995
NM_024076

NM_146188
NM_001360818
NM_001360820

RefSeq (protein)

NP_001123466
NP_001123467
NP_076981

NP_666300
NP_001347747
NP_001347749

Location (UCSC)Chr 19: 33.8 – 33.82 MbChr 7: 34.34 – 34.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel tetramerisation domain containing 15 also known as BTB/POZ domain-containing protein KCTD15 is protein that in humans is encoded by the KCTD15 gene.[5]

Clinical significance

Variants of the KCTD15 gene may be associated with obesity.[6][7][8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153885 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030499 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. S2CID 764409.
  7. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
  8. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790.

Further reading

  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring). 18 (6): 1212–7. doi:10.1038/oby.2009.413. PMID 19910938. S2CID 9601431.
  • Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
  • Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
  • Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • He M, Cornelis MC, Franks PW, et al. (2010). "Obesity Genotype Score and Cardiovascular Risk in Women with Type 2 Diabetes". Arterioscler. Thromb. Vasc. Biol. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC 3061473. PMID 19910641.
  • Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.


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