KDM8 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1 |
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Identifiers |
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Aliases | KDM8, JMJD5, lysine demethylase 8 |
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External IDs | OMIM: 611917; MGI: 1924285; HomoloGene: 49791; GeneCards: KDM8; OMA:KDM8 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16p12.1 | Start | 27,203,508 bp[1] |
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End | 27,221,768 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F3 | Start | 125,043,848 bp[2] |
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End | 125,061,441 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right lobe of liver
- duodenum
- testicle
- gonad
- granulocyte
- apex of heart
- epithelium of colon
- body of pancreas
- prefrontal cortex
- mucosa of transverse colon
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| Top expressed in | - retinal pigment epithelium
- primitive streak
- cumulus cell
- neural layer of retina
- embryo
- morula
- secondary oocyte
- ventricular zone
- triceps brachii muscle
- Rostral migratory stream
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - dioxygenase activity
- chromatin binding
- oxidoreductase activity
- metal ion binding
- histone H3-methyl-lysine-36 demethylase activity
- histone demethylase activity
- protein binding
- peptidase activity
- hydrolase activity
- aminopeptidase activity
- endopeptidase activity
- 2-oxoglutarate-dependent dioxygenase activity
- methylated histone binding
| Cellular component | - nucleus
- nucleoplasm
- cytosol
- chromosome
| Biological process | - regulation of transcription, DNA-templated
- cell cycle
- G2/M transition of mitotic cell cycle
- positive regulation of transcription, DNA-templated
- histone H3-K36 demethylation
- transcription, DNA-templated
- proteolysis
- chromatin organization
- protein destabilization
- circadian regulation of gene expression
- negative regulation of transcription, DNA-templated
- rhythmic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 27.2 – 27.22 Mb | Chr 7: 125.04 – 125.06 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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