KIRREL2

Protein-coding gene in the species Homo sapiens
KIRREL2
Identifiers
AliasesKIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDsOMIM: 607762; MGI: 2442334; HomoloGene: 35249; GeneCards: KIRREL2; OMA:KIRREL2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KIRREL2
Genomic location for KIRREL2
Band19q13.12Start35,855,861 bp[1]
End35,867,136 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for KIRREL2
Genomic location for KIRREL2
Band7|7 B1Start30,146,959 bp[2]
End30,157,115 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • islet of Langerhans

  • ventricular zone

  • ganglionic eminence

  • retinal pigment epithelium

  • prefrontal cortex

  • external globus pallidus

  • lymph node

  • Brodmann area 9

  • cingulate gyrus
Top expressed in
  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • white matter of cerebellum

  • respiratory epithelium

  • striatum of neuraxis

  • islet of Langerhans

  • spinal cord

  • nasal epithelium

  • rhombic lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
Cellular component
  • integral component of membrane
  • slit diaphragm
  • membrane
  • plasma membrane
  • cell-cell junction
Biological process
  • negative regulation of protein phosphorylation
  • cell adhesion
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84063

243911

Ensembl

ENSG00000126259

ENSMUSG00000036915

UniProt

Q6UWL6

Q7TSU7

RefSeq (mRNA)

NM_032123
NM_199179
NM_199180
NM_001329530
NM_001363667

NM_172898

RefSeq (protein)

NP_001316459
NP_115499
NP_954648
NP_954649
NP_001350596

NP_766486

Location (UCSC)Chr 19: 35.86 – 35.87 MbChr 7: 30.15 – 30.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.[5][6][7] It is primarily expressed in β cells of the pancreatic islets.[5]

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126259 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036915 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
  6. ^ Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
  7. ^ "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999. S2CID 30494486.


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