Keith R. Jerome
Keith R. Jerome | |
---|---|
Education | Georgetown College Duke University |
Scientific career | |
Fields | Virology |
Institutions | University of Washington |
Keith R. Jerome is an American virologist whose research focuses on viruses such as herpes simplex, HIV and hepatitis B that persist in their hosts. He published on the first known case of COVID-19 in the United States detecting SARS-CoV-2 in Washington State[1] and helped forge the nation's COVID-19 testing.[2][3][4] In 2021, Jerome and Alexander Greninger shared the Washington Innovator of the Year award for developing the laboratory based assay for detecting COVID-19.[5] He was senior author on a research article published in Science describing the cryptic transmission of SARS-CoV-2 alongside Trevor Bedford, Alexander Greninger, Jay Shendure, and Helen Chu.[6] Regarding the origin of SARS-CoV-2 he reported that the live market in Wuhan was more likely than a lab leak of the virus.[7]
Jerome studies the ways in which these viruses evade the immune system and potential therapies for these infections. Jerome and his colleagues study the uses of precision gene-editing tools like CRISPR/Cas9 to remove damaging viral genes that have tucked themselves into a person's genetic code or to insert genes that can protect cells from invading viruses. He has been working for years on research aimed at a cure for Herpes virus by using the DNA-cutting tools of gene therapy. Initial research showed these techniques could knock out small quantities of latent virus.[8] He and his colleagues are exploring this approach in combination with blood stem cell transplants as a means of curing HIV.
Academic and medical appointments
- Professor, Department of Laboratory Medicine and Pathology, University of Washington, 2012–present
- Head, Virology Division, Laboratory Medicine, University of Washington, 2012–present
- Full professor, Fred Hutchinson Cancer Research Center, 2015–present
Education and training
- Georgetown College, B.S., Chemistry, summa cum laude, 1985
- Duke University, PhD, Microbiology and Immunology, 1992
- Duke University, MD, May 1993
- Resident Physician, Department of Pathology, University of Washington, 1993-1995
- Resident Physician, Department of Laboratory Medicine, University of Washington, 1995-1997
- Senior Fellow, Virology Division, Department of Laboratory Medicine, University of Washington, 1997-1998
Selected publications
- Jerome, Keith R.; Barnd, Donna L.; Bendt, Katharine M.; et al. (1991-06-01). "Cytotoxic T-Lymphocytes Derived from Patients with Breast Adenocarcinoma Recognize an Epitope Present on the Protein Core of a Mucin Molecule Preferentially Expressed by Malignant Cells". Cancer Research. 51 (11): 2908–2916.
- Jerome, Keith R.; Fox, Richard; Chen, Zheng; et al. (1999-11-01). "Herpes Simplex Virus Inhibits Apoptosis through the Action of Two Genes, Us5 and Us3". Journal of Virology. 73 (11): 8950–8957. doi:10.1128/jvi.73.11.8950-8957.1999. PMC 112926. PMID 10516000.
- Bhatraju, Pavan K.; Ghassemieh, Bijan J.; Nichols, Michelle; et al. (2020-05-21). "Covid-19 in Critically Ill Patients in the Seattle Region - Case Series". The New England Journal of Medicine. 382 (21): 2012–2022. doi:10.1056/NEJMoa2004500. PMC 7143164. PMID 32227758.
- Nalla, Arun K.; Casto, Amanda M.; Huang, Meei-Li W.; et al. (2020-05-26). "Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit". Journal of Clinical Microbiology. 58 (6): e00557-20. doi:10.1128/jcm.00557-20. PMC 7269385. PMID 32269100.
- Joung, Julia; Ladha, Alim; Saito, Makoto; et al. (2020-09-16). "Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing". New England Journal of Medicine. 383 (15): 1492–1494. doi:10.1056/NEJMc2026172. PMC 7510942. PMID 32937062.
- Bedford, Trevor; Greninger, Alexander L.; Roychoudhury, Pavitra; et al. (2020-09-10). "Cryptic transmission of SARS-CoV-2 in Washington state". Science. 370 (6516): 571–575. doi:10.1126/science.abc0523. PMC 7276023. PMID 32511596.
- Perchetti, Garrett A.; Huang, Meei-Li; Mills, Margaret G.; Jerome, Keith R.; Greninger, Alexander L. (2021-02-18). "Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card". Clinical Microbiology. 59 (3): e02880-20. doi:10.1128/jcm.02880-20. PMC 8106729. PMID 33310764.
References
- ^ Bhatraju, Pavan K.; Ghassemieh, Bijan J.; Nichols, Michelle; Kim, Richard; Jerome, Keith R.; Nalla, Arun K.; Greninger, Alexander L.; Pipavath, Sudhakar; Wurfel, Mark M.; Evans, Laura; Kritek, Patricia A.; West, T. Eoin; Luks, Andrew; Gerbino, Anthony; Dale, Chris R.; Goldman, Jason D.; O'Mahony, Shane; Mikacenic, Carmen (May 21, 2020). "Covid-19 in Critically Ill Patients in the Seattle Region - Case Series". The New England Journal of Medicine. 382 (21): 2012–2022. doi:10.1056/NEJMoa2004500. PMC 7143164. PMID 32227758.
- ^ "How UW's Virology Lab Helped Forge the Nation's Covid-19 Testing". Seattle Met.
- ^ "When Coronavirus Struck Seattle, This Lab Was Ready To Start Testing". NPR.
- ^ Maxmen, Amy (March 6, 2020). "The race to unravel the biggest coronavirus outbreak in the United States". Nature. 579 (7798): 181–182. Bibcode:2020Natur.579..181M. doi:10.1038/d41586-020-00676-3. PMID 32152595. S2CID 212655031.
- ^ "Innovator of the Year awarded to directors of virology lab". newsroom.uw.edu. April 28, 2021.
- ^ Bedford, Trevor; Greninger, Alexander L.; Roychoudhury, Pavitra; Starita, Lea M.; Famulare, Michael; Huang, Meei-Li; Nalla, Arun; Pepper, Gregory; Reinhardt, Adam; Xie, Hong; Shrestha, Lasata; Nguyen, Truong N.; Adler, Amanda; Brandstetter, Elisabeth; Cho, Shari; Giroux, Danielle; Han, Peter D.; Fay, Kairsten; Frazar, Chris D.; Ilcisin, Misja; Lacombe, Kirsten; Lee, Jover; Kiavand, Anahita; Richardson, Matthew; Sibley, Thomas R.; Truong, Melissa; Wolf, Caitlin R.; Nickerson, Deborah A.; Rieder, Mark J.; Englund, Janet A.; Hadfield, James; Hodcroft, Emma B.; Huddleston, John; Moncla, Louise H.; Müller, Nicola F.; Neher, Richard A.; Deng, Xianding; Gu, Wei; Federman, Scot; Chiu, Charles; Duchin, Jeffrey S.; Gautom, Romesh; Melly, Geoff; Hiatt, Brian; Dykema, Philip; Lindquist, Scott; Queen, Krista; Tao, Ying; Uehara, Anna; Tong, Suxiang; MacCannell, Duncan; Armstrong, Gregory L.; Baird, Geoffrey S.; Chu, Helen Y.; Shendure, Jay; Jerome, Keith R. (October 30, 2020). "Cryptic transmission of SARS-CoV-2 in Washington state". Science. 370 (6516): 571–575. doi:10.1126/science.abc0523. PMC 7810035. PMID 32913002.
- ^ "UW Medicine's head of Virology: Live market 'more likely the start' of COVID". MyNorthwest.com. November 28, 2021.
- ^ Russell, Sabin (2020-08-18). "A cure for herpes? There is progress to report". Fred Hutch. Retrieved 2022-04-03.