LCTL

Protein-coding gene in the species Homo sapiens
LCTL
Identifiers
AliasesLCTL, KLG, KLPH, lactase like
External IDsOMIM: 617060; MGI: 2183549; HomoloGene: 70710; GeneCards: LCTL; OMA:LCTL - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for LCTL
Genomic location for LCTL
Band15q22.31Start66,547,179 bp[1]
End66,565,998 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for LCTL
Genomic location for LCTL
Band9|9 CStart64,024,429 bp[2]
End64,045,400 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • testicle

  • C1 segment

  • gonad

  • stromal cell of endometrium

  • caudate nucleus

  • nucleus accumbens

  • amygdala

  • ventricular zone

  • putamen
Top expressed in
  • lens

  • white adipose tissue

  • morula

  • blastocyst

  • right kidney

  • human kidney

  • primary oocyte

  • ovary

  • secondary oocyte

  • skeletal muscle tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • beta-glucosidase activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • brush border
  • membrane
  • endoplasmic reticulum
Biological process
  • glycosyl compound metabolic process
  • carbohydrate metabolic process
  • lens morphogenesis in camera-type eye
  • visual perception
  • response to stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

197021

235435

Ensembl

ENSG00000188501

ENSMUSG00000032401

UniProt

Q6UWM7

Q8K1F9

RefSeq (mRNA)

NM_001278562
NM_207338
NM_001394632
NM_001394633

NM_145835

RefSeq (protein)

NP_001265491
NP_997221

NP_665834

Location (UCSC)Chr 15: 66.55 – 66.57 MbChr 9: 64.02 – 64.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lactase-like is a protein that in humans is encoded by the LCTL gene.[5] Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188501 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032401 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lactase-like". Retrieved 2013-09-25.

Further reading

  • Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE (December 2011). "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry. 286 (50): 43294–300. doi:10.1074/jbc.M111.267641. PMC 3234855. PMID 22020932.
  • Mian IS (June 1998). "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases. 24 (2): 83–100. doi:10.1006/bcmd.1998.9998. PMID 9779294.
  • Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y (July 2002). "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576 (3): 341–5. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582.
  • v
  • t
  • e

This article incorporates text from the United States National Library of Medicine, which is in the public domain.