Protein-coding gene in the species Homo sapiens
LIM2 |
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Identifiers |
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Aliases | LIM2, CTRCT19, MP17, MP19, lens intrinsic membrane protein 2 |
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External IDs | OMIM: 154045; MGI: 104698; HomoloGene: 12744; GeneCards: LIM2; OMA:LIM2 - orthologs |
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Gene location (Human) |
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![Chromosome 19 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png) | Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.41 | Start | 51,379,909 bp[1] |
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End | 51,387,974 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 B3|7 28.25 cM | Start | 43,079,512 bp[2] |
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End | 43,085,420 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- lens
- granulocyte
- retinal pigment epithelium
- blood
- bone marrow
- apex of heart
- placenta
- lower respiratory tract
- spleen
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| Top expressed in | - lens
- embryo
- morula
- neural layer of retina
- blastocyst
- bone marrow
- stomach
- intestine
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PBB_GE_LIM2_220519_s_at_fs.png/250px-PBB_GE_LIM2_220519_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - structural constituent of eye lens
| Cellular component | - integral component of membrane
- vesicle
- cell junction
- plasma membrane
- membrane
| Biological process | - camera-type eye development
- lens development in camera-type eye
- cell-cell junction assembly
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 19: 51.38 – 51.39 Mb | Chr 7: 43.08 – 43.09 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.[5][6]
The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1; MIM 123660). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD.
This protein appears to contain 4 transmembrane domains, is a substrate for cAMP-dependent protein kinase and protein kinase C, and binds with calmodulin. Taken together, these suggest that MP19 functions in some way as a junctional component, possibly involved with lens cell communication. It has been shown to be involved with cataractogenesis.[supplied by OMIM][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105370 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000118560 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Church RL, Wang J (Jul 1992). "Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19". Curr Eye Res. 11 (5): 421–4. doi:10.3109/02713689209001795. PMID 1606837.
- ^ a b "Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa".
Further reading
- Louis CF, Hur KC, Galvan AC, et al. (1989). "Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes". J. Biol. Chem. 264 (33): 19967–73. doi:10.1016/S0021-9258(19)47205-0. PMID 2584203.
- Church RL, Wang JH (1994). "The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis". Curr. Eye Res. 12 (12): 1057–65. doi:10.3109/02713689309033503. PMID 8137630.
- Lieuallen K, Christensen M, Brandriff B, et al. (1994). "Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB". Somat. Cell Mol. Genet. 20 (1): 67–9. doi:10.1007/BF02257488. PMID 8197479. S2CID 45812361.
- Kerscher S, Church RL, Boyd Y, Lyon MF (1996). "Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19)". Genomics. 29 (2): 445–50. doi:10.1006/geno.1995.9983. PMID 8666393.
- Gonen T, Grey AC, Jacobs MD, et al. (2002). "MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3". BMC Cell Biol. 2: 17. doi:10.1186/1471-2121-2-17. PMC 48140. PMID 11532191.
- Pras E, Levy-Nissenbaum E, Bakhan T, et al. (2002). "A Missense Mutation in the LIM2 Gene Is Associated with Autosomal Recessive Presenile Cataract in an Inbred Iraqi Jewish Family". Am. J. Hum. Genet. 70 (5): 1363–7. doi:10.1086/340318. PMC 447612. PMID 11917274.
- Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
- Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.