MPDZ

Protein-coding gene in the species Homo sapiens

MPDZ

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2FCF, 2FNE, 2IWN, 2IWO, 2IWP, 2IWQ, 2O2T, 2OPG, 2QG1

Identifiers

Aliases

MPDZ, HYC2, MUPP1, multiple PDZ domain crumbs cell polarity complex component

External IDs

OMIM: 603785; MGI: 1343489; HomoloGene: 2841; GeneCards: MPDZ; OMA:MPDZ - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p23	Start	13,105,704 bp^[1]
Band	9p23	End	13,279,590 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 C3\|4 38.0 cM	Start	81,278,500 bp^[2]
Band	4 C3\|4 38.0 cM	End	81,442,815 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

corpus callosum

ventricular zone

subthalamic nucleus

inferior ganglion of vagus nerve

Epithelium of choroid plexus

external globus pallidus

superior vestibular nucleus

vena cava

pars reticulata

Top expressed in

epithelium of lens

tail of embryo

vestibular sensory epithelium

digastric muscle

neural layer of retina

sciatic nerve

genital tubercle

vastus lateralis muscle

iris

efferent ductule

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein C-terminus binding protein binding
Cellular component	cytoplasm neuron projection cell junction apicolateral plasma membrane dendrite postsynaptic membrane plasma membrane cell projection synapse apical plasma membrane Schmidt-Lanterman incisure cytoplasmic vesicle postsynaptic density membrane bicellular tight junction
Biological process	cell adhesion viral process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8777


17475

Ensembl


ENSG00000107186


ENSMUSG00000028402

UniProt


O75970


Q8VBX6

RefSeq (mRNA)


NM_001261406 NM_001261407 NM_003829 NM_001330637


NM_010820 NM_001305284 NM_001305286

RefSeq (protein)

NP_001248335 NP_001248336 NP_001317566 NP_003820 NP_001362342
NP_001362345 NP_001362346 NP_001362347 NP_001362348 NP_001362349 NP_001362350 NP_001362351 NP_001362352 NP_001362353 NP_001362354 NP_001362355 NP_001362356 NP_001365707


NP_001292213 NP_001292215 NP_034950

Location (UCSC)

Chr 9: 13.11 – 13.28 Mb

Chr 4: 81.28 – 81.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.^[5]

Interactions

MPDZ has been shown to interact with:

5-HT2C receptor,^[6]^[7]
CD117,^[8] and
PLEKHA1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107186 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028402 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MPDZ multiple PDZ domain protein".
^ Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294.
^ Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi:10.1016/s0014-5793(98)00141-0. PMID 9537516. S2CID 25328791.
^ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/s0014-5793(00)02036-6. PMID 11018522. S2CID 40159587.
^ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

Ullmer C, Schmuck K, Figge A, Lübbert H (1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. S2CID 25328791.
Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". J. Cell. Biochem. 79 (2): 213–24. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMC 3501957. PMID 10967549.
Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT (2000). "Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins". J. Virol. 74 (20): 9680–93. doi:10.1128/JVI.74.20.9680-9693.2000. PMC 112400. PMID 11000240.
Mancini A, Koch A, Stefan M, Niemann H, Tamura T (2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/S0014-5793(00)02036-6. PMID 11018522. S2CID 40159587.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294.
Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S (2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. Chem. 277 (1): 455–61. doi:10.1074/jbc.M109005200. hdl:2433/148697. PMID 11689568.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002). "Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells". J. Cell Biol. 159 (2): 361–72. doi:10.1083/jcb.200207050. PMC 2173042. PMID 12403818.
Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE (2004). "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation". Neuron. 43 (4): 563–74. doi:10.1016/j.neuron.2004.08.003. PMID 15312654. S2CID 17190912.
van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass P, Le Bivic A, Wijnholds J (2005). "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure". J. Cell Sci. 117 (Pt 18): 4169–77. doi:10.1242/jcs.01301. PMID 15316081.
Coyne CB, Voelker T, Pichla SL, Bergelson JM (2005). "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction". J. Biol. Chem. 279 (46): 48079–84. doi:10.1074/jbc.M409061200. PMID 15364909.
Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269.
Heydecke D, Meyer D, Ackermann F, Wilhelm B, Gudermann T, Boekhoff I (2006). "The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa". J. Androl. 27 (3): 390–404. doi:10.2164/jandrol.05166. PMID 16452527.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.