MPP2

Protein-coding gene in the species Homo sapiens
MPP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E7K

Identifiers
AliasesMPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDsOMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MPP2
Genomic location for MPP2
Band17q21.31Start43,875,357 bp[1]
End43,909,711 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MPP2
Genomic location for MPP2
Band11 D|11 65.48 cMStart101,947,841 bp[2]
End101,979,341 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • prefrontal cortex

  • right hemisphere of cerebellum

  • right frontal lobe

  • hypothalamus

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • amygdala

  • substantia nigra
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • subiculum

  • superior frontal gyrus

  • piriform cortex

  • dorsomedial hypothalamic nucleus

  • neural layer of retina

  • superior colliculus

  • primary motor cortex

  • anterior amygdaloid area
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • guanylate kinase activity
  • protein binding
Cellular component
  • integral component of plasma membrane
  • postsynaptic density
  • dendrite membrane
  • dendritic spine
  • dendritic shaft
  • cytoplasm
  • cytoskeleton
  • plasma membrane
  • membrane
  • dendrite
  • dendritic spine membrane
  • cell projection
Biological process
  • signal transduction
  • GMP metabolic process
  • GDP metabolic process
  • protein homooligomerization
  • excitatory postsynaptic potential
  • long-term potentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4355

50997

Ensembl

ENSG00000108852

ENSMUSG00000017314

UniProt

Q14168

Q9WV34

RefSeq (mRNA)
NM_001278370
NM_001278371
NM_001278372
NM_001278373
NM_001278374

NM_001278375
NM_001278376
NM_001278381
NM_005374

NM_016695
NM_001356324

RefSeq (protein)
NP_001265299
NP_001265300
NP_001265301
NP_001265302
NP_001265303

NP_001265304
NP_001265305
NP_001265310
NP_005365

NP_057904
NP_001343253

Location (UCSC)Chr 17: 43.88 – 43.91 MbChr 11: 101.95 – 101.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.[5][6]

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108852 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017314 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
  6. ^ a b "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Smith SA, Holik P, Stevens J, et al. (1997). "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21". Genomics. 31 (2): 145–50. doi:10.1006/geno.1996.0025. PMID 8824795.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wierstra I, Alves J (2006). "Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains". Biol. Chem. 387 (7): 963–76. doi:10.1515/BC.2006.120. PMID 16913846. S2CID 25571232.


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