MRCL3

Protein-coding gene in the species Homo sapiens
MYL12A
Identifiers
AliasesMYL12A, HEL-S-24, MLCB, MRCL3, MRLC3, MYL2B, MLC-2B, myosin light chain 12A
External IDsMGI: 107494; HomoloGene: 23407; GeneCards: MYL12A; OMA:MYL12A - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for MYL12A
Genomic location for MYL12A
Band18p11.31Start3,247,481 bp[1]
End3,256,236 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for MYL12A
Genomic location for MYL12A
Band17|17 E1.3Start71,280,128 bp[2]
End71,297,885 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • muscle of thigh

  • right auricle

  • monocyte

  • right lung

  • granulocyte

  • upper lobe of left lung

  • right coronary artery

  • ascending aorta

  • left coronary artery
Top expressed in
  • granulocyte

  • primary visual cortex

  • superior frontal gyrus

  • yolk sac

  • lip

  • right kidney

  • dentate gyrus of hippocampal formation granule cell

  • ventricular zone

  • embryo

  • blastocyst
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • protein binding
  • metal ion binding
  • myosin heavy chain binding
Cellular component
  • cytosol
  • extracellular exosome
  • myosin complex
  • myosin II complex
  • apical part of cell
  • Z discdkac
  • brush border
  • stress fiber
  • cell cortex region
Biological process
  • ephrin receptor signaling pathway
  • muscle contraction
  • platelet aggregation
  • regulation of cell shape
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10627

67938

Ensembl

ENSG00000101608

ENSMUSG00000034868

UniProt

P19105
O14950

Q3THE2

RefSeq (mRNA)

NM_001303047
NM_001303048
NM_001303049
NM_006471

NM_023402

RefSeq (protein)
NP_001289976
NP_001289977
NP_001289978
NP_006462
NP_001138416

NP_001138417
NP_291024
NP_001289976
NP_001289977
NP_001289978
NP_006462

NP_075891

Location (UCSC)Chr 18: 3.25 – 3.26 MbChr 17: 71.28 – 71.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin regulatory light chain 12A is a protein that in humans is encoded by the MYL12A gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101608 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034868 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grant JW, Zhong RQ, McEwen PM, Church SL (Nov 1990). "Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA". Nucleic Acids Res. 18 (19): 5892. doi:10.1093/nar/18.19.5892. PMC 332341. PMID 2216787.
  6. ^ "Entrez Gene: MRCL3 myosin regulatory light chain MRCL3".

Further reading

  • Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H (2002). "Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells". Cell Struct. Funct. 26 (6): 677–83. doi:10.1247/csf.26.677. PMID 11942626.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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