MTUS1

Mammalian protein found in Homo sapiens
MTUS1
Identifiers
AliasesMTUS1, ATBP, ATIP, ICIS, MP44, MTSG1, microtubule associated tumor suppressor 1, microtubule associated scaffold protein 1, ATIP3
External IDsOMIM: 609589; MGI: 2142572; HomoloGene: 100292; GeneCards: MTUS1; OMA:MTUS1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MTUS1
Genomic location for MTUS1
Band8p22Start17,643,795 bp[1]
End17,801,094 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for MTUS1
Genomic location for MTUS1
Band8|8 A4Start41,443,951 bp[2]
End41,586,763 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • inferior ganglion of vagus nerve

  • inferior olivary nucleus

  • body of pancreas

  • thoracic diaphragm

  • right ventricle

  • subthalamic nucleus

  • biceps brachii

  • C1 segment

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • granulocyte

  • interventricular septum

  • lobe of cerebellum

  • cerebellar vermis

  • myocardium of ventricle

  • aortic valve

  • knee joint
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • microtubule binding
Cellular component
  • cytoplasm
  • plasma membrane
  • Golgi apparatus
  • spindle
  • microtubule
  • cytoskeleton
  • membrane
  • mitochondrion
  • nucleus
  • microtubule organizing center
  • extracellular space
  • nucleolus
  • microtubule cytoskeleton
Biological process
  • regulation of macrophage chemotaxis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57509

102103

Ensembl

ENSG00000129422

ENSMUSG00000045636

UniProt

Q9ULD2

Q5HZI1

RefSeq (mRNA)
NM_001001924
NM_001001925
NM_001001927
NM_001001931
NM_001166393

NM_020749
NM_001330470
NM_001363057
NM_001363058
NM_001363059
NM_001363060
NM_001363061
NM_001363062

NM_001005863
NM_001005864
NM_001005865
NM_001286413

RefSeq (protein)
NP_001001924
NP_001001925
NP_001001931
NP_001159865
NP_001317399

NP_065800
NP_001349986
NP_001349987
NP_001349988
NP_001349989
NP_001349990
NP_001349991

NP_001005863
NP_001005864
NP_001005865
NP_001273342
NP_001390875

NP_001390876
NP_001390879
NP_001390881
NP_001390883
NP_001390884
NP_001390885

Location (UCSC)Chr 8: 17.64 – 17.8 MbChr 8: 41.44 – 41.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans.[5][6] Expression levels of MTUS1 was reported to be lost in various types of human malignancies such as colon, ovarian, head-and-neck, pancreas, breast cancers, bladder, gastric, and lung cancers.[7][8]

Proteins encoded by MTUS1

As a result of alternative splicing MTUS1 was shown to encode 5 different protein isoforms as listed as ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP3a and ATIP3b was generally considered as ATIP3 and ATIP1 and ATIP3 is the major splice variants encoded by MTUS1 gene.[9]

Function

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotensin II receptor type 2 (AT2) and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.[10]

Interactions

MTUS1 has been shown to interact with Angiotensin II receptor type 2.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129422 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045636 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kara M, Kaplan M, Bozgeyik I, Ozcan O, Celik OI, Bozgeyik E, Yumrutas O (August 2016). "MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer". Gene. 587 (2): 173–7. doi:10.1016/j.gene.2016.05.006. PMID 27155522.
  6. ^ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  7. ^ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  8. ^ Ozcan O, Kara M, Yumrutas O, Bozgeyik E, Bozgeyik I, Celik OI (May 2016). "MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations". Tumour Biology. 37 (5): 6637–45. doi:10.1007/s13277-015-4550-4. PMID 26643896. S2CID 25574850.
  9. ^ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  10. ^ "Entrez Gene: MTUS1 mitochondrial tumor suppressor 1".
  11. ^ Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.

Further reading

  • Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C (June 2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma". Molecular and Cellular Endocrinology. 252 (1–2): 207–15. doi:10.1016/j.mce.2006.03.014. PMID 16650523. S2CID 19420252.
  • Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B (July 2007). "Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk". Carcinogenesis. 28 (7): 1442–5. doi:10.1093/carcin/bgm033. PMID 17301065.
  • Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C (October 2006). "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP". Gene. 380 (2): 127–36. doi:10.1016/j.gene.2006.05.021. PMID 16887298.
  • Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.
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