MT3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/dc/Protein_MT3_PDB_2f5h.png/250px-Protein_MT3_PDB_2f5h.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2F5H, 2FJ4, 2FJ5 |
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Identifiers |
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Aliases | MT3, GIF, GIFB, GRIF, Znmetallothionein 3 |
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External IDs | OMIM: 139255; MGI: 97173; HomoloGene: 136800; GeneCards: MT3; OMA:MT3 - orthologs |
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Gene location (Human) |
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![Chromosome 16 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png) | Chr. | Chromosome 16 (human)[1] |
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| Band | 16q13 | Start | 56,589,074 bp[1] |
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End | 56,591,088 bp[1] |
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Gene location (Mouse) |
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![Chromosome 8 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png) | Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8 C5|8 46.29 cM | Start | 94,879,235 bp[2] |
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End | 94,880,774 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - nucleus accumbens
- putamen
- Brodmann area 9
- temporal lobe
- amygdala
- substantia nigra
- caudate nucleus
- right frontal lobe
- prefrontal cortex
- hippocampus proper
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| Top expressed in | - choroid plexus of fourth ventricle
- dentate gyrus of hippocampal formation granule cell
- perirhinal cortex
- entorhinal cortex
- CA3 field
- primary visual cortex
- superior frontal gyrus
- dorsomedial hypothalamic nucleus
- superior colliculus
- central gray substance of midbrain
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PBB_GE_MT3_205970_at_fs.png/250px-PBB_GE_MT3_205970_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - zinc ion binding
- protein kinase activator activity
- metal ion binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- antioxidant activity
- protein binding
- copper ion binding
- cadmium ion binding
| Cellular component | - cytoplasm
- cytosol
- rough endoplasmic reticulum
- ribosome
- astrocyte end-foot
- postsynaptic density
- synaptic vesicle
- plasma membrane
- dendritic spine
- astrocyte projection
- intracellular anatomical structure
- mitochondrial outer membrane
- axon
- inclusion body
- perinuclear region of cytoplasm
- microtubule
- extracellular space
- nucleus
| Biological process | - negative regulation of neuron apoptotic process
- positive regulation of necrotic cell death
- cellular lipid catabolic process
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- activation of protein kinase B activity
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of cell death
- response to hypoxia
- zinc ion homeostasis
- protein kinase B signaling
- histone modification
- leptin-mediated signaling pathway
- removal of superoxide radicals
- astrocyte development
- ERK1 and ERK2 cascade
- negative regulation of neurogenesis
- regulation of response to food
- protein stabilization
- zinc ion transport
- response to metal ion
- negative regulation of apoptotic process
- positive regulation of catalytic activity
- cholesterol catabolic process
- cellular response to cadmium ion
- cellular metal ion homeostasis
- cadmium ion homeostasis
- response to oxidative stress
- negative regulation of hydrogen peroxide catabolic process
- negative regulation of cysteine-type endopeptidase activity
- positive regulation of transcription, DNA-templated
- brain development
- positive regulation of gene expression
- positive regulation of lysosomal membrane permeability
- cellular zinc ion homeostasis
- negative regulation of cell growth
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
- negative regulation of oxidoreductase activity
- regulation of protein glycosylation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of oxygen metabolic process
- cellular response to oxidative stress
- cellular response to nitric oxide
- negative regulation of reactive oxygen species metabolic process
- energy reserve metabolic process
- cell population proliferation
- negative regulation of autophagy
- negative regulation of transcription, DNA-templated
- negative regulation of axon extension
- negative regulation of necrotic cell death
- cellular response to hypoxia
- negative regulation of neuron death
- apoptotic process
- detoxification of copper ion
- cellular response to copper ion
- cellular response to zinc ion
- negative regulation of neuron projection development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 56.59 – 56.59 Mb | Chr 8: 94.88 – 94.88 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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